Department of Rheumatology and Immunology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China.
Department of Rheumatology and Immunology, Shenzhen Second People's Hospital, Shenzhen, China.
Front Immunol. 2022 Feb 3;13:757802. doi: 10.3389/fimmu.2022.757802. eCollection 2022.
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis characterized by IgA deposits in the mesangial area of glomeruli. Connective tissue disorders are some of the most frequent causes of secondary IgAN. Nevertheless, IgAN rarely occurs in systemic autoimmune myopathies (SAMs). The present case study reports on a 58-year-old patient with dermatomyositis with positive anti-transcription intermediary factor (TIF)-1γ antibodies who was diagnosed with IgAN during standard immunosuppressive therapy. Moreover, we have made a systematic review regarding the association of SAMs and IgAN. To the best of the authors' knowledge, this is the first case study describing a patient with anti-TIF1γ antibody-positive dermatomyositis who developed IgAN, which demonstrates a potential relationship between anti-TIF1γ-positive dermatomyositis and IgAN. It is important for clinicians to be aware of the possibility of renal involvement in patients with SAMs, even in those with anti-TIF1γ-positive dermatomyositis.
免疫球蛋白 A 肾病（IgAN）是最常见的原发性肾小球肾炎，其特征是 IgA 在肾小球系膜区沉积。结缔组织疾病是继发性 IgAN 的最常见原因之一。然而，IgAN 在系统性自身免疫性肌病（SAMs）中很少见。本病例研究报告了一例 58 岁皮肌炎患者，其抗转录中介因子（TIF）-1γ 抗体呈阳性，在标准免疫抑制治疗期间被诊断为 IgAN。此外，我们对 SAMs 和 IgAN 的相关性进行了系统综述。据作者所知，这是首例描述抗 TIF1γ 抗体阳性皮肌炎患者发生 IgAN 的病例研究，表明抗 TIF1γ 阳性皮肌炎与 IgAN 之间可能存在关联。临床医生应该意识到 SAMs 患者可能会出现肾脏受累，即使是抗 TIF1γ 阳性皮肌炎患者也是如此。
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