Rochiccioli P, Pienkowski C, Bouissou F, Sablayrolles B, Barthe P
Arch Fr Pediatr. 1986 Jan;43(1):51-3.
The authors report a case of chronic renal failure with a -4 SD growth retardation. The patient underwent dialysis and then transplantation. Investigations to determine somatotropin deficiency showed dissociated results of 4 stimulation tests: 2 normal responses and 2 low responses. Treatment with human growth hormone (10 mg/kg/year) induced a dramatic acceleration of the growth velocity, which increased from 2 to 7 cm/year. After 18 months, the gain in height was 10 cm. Data submitted by several authors on Cushing's disease and the interrelations cortisone/somatotropin secretion suggest that continuous and/or alternate corticotherapy may be the cause of this partial somatotropin deficiency.
作者报告了一例伴有-4标准差生长迟缓的慢性肾衰竭病例。该患者接受了透析，随后进行了移植。确定生长激素缺乏的检查显示4次刺激试验结果不一致：2次正常反应和2次低反应。使用人生长激素（10mg/kg/年）治疗使生长速度显著加快，从每年2厘米增加到7厘米。18个月后，身高增加了10厘米。几位作者提交的关于库欣病以及可的松/生长激素分泌相互关系的数据表明，持续和/或交替使用皮质激素治疗可能是这种部分生长激素缺乏的原因。
