• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

复制独立突变的合并。

The coalescent with replication-independent mutations.

机构信息

Department of Mathematics and Statistical Science, University of Idaho, Moscow, Idaho, United States.

出版信息

PeerJ. 2022 Feb 15;10:e12926. doi: 10.7717/peerj.12926. eCollection 2022.

DOI:10.7717/peerj.12926
PMID:35186495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8855725/
Abstract

We develop the mathematical structure of the neutral coalescent with both replication-dependent and replication-independent mutations. This allows us to explain and quantify empirical results that explore differences in genetic diversity in bacterial cultures with different growth rates. We also derive an unbiased and consistent estimator for the replication-independent mutation rate that is based on a comparison of total single nucleotide polymorphism counts for two independent well-mixed cultures with different growth rates. In addition to explaining differences in genetic diversity between well-mixed cultures with different (but constant) growth rates, our coalescent also quantifies the effects of fluctuating growth rates-a situation that can be common in natural populations.

摘要

我们发展了具有复制依赖和复制独立突变的中性合并的数学结构。这使我们能够解释和量化经验结果，这些结果探索了具有不同生长速率的细菌培养物中遗传多样性的差异。我们还基于对两个具有不同生长速率的独立充分混合培养物的总单核苷酸多态性计数的比较，推导出了一个无偏且一致的复制独立突变率估计值。除了解释具有不同（但恒定）生长速率的充分混合培养物之间遗传多样性的差异外，我们的合并还量化了波动生长速率的影响 - 这种情况在自然种群中可能很常见。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/8eab14ab27d5/peerj-10-12926-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/65234eb41328/peerj-10-12926-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/19f967e6d2ae/peerj-10-12926-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/0e4d90daf2cb/peerj-10-12926-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/7ddb9a09074f/peerj-10-12926-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/00894374fdc1/peerj-10-12926-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/a96cab8e8b85/peerj-10-12926-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/8eab14ab27d5/peerj-10-12926-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/65234eb41328/peerj-10-12926-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/19f967e6d2ae/peerj-10-12926-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/0e4d90daf2cb/peerj-10-12926-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/7ddb9a09074f/peerj-10-12926-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/00894374fdc1/peerj-10-12926-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/a96cab8e8b85/peerj-10-12926-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4454/8855725/8eab14ab27d5/peerj-10-12926-g007.jpg

相似文献

1
The coalescent with replication-independent mutations.复制独立突变的合并。
PeerJ. 2022 Feb 15;10:e12926. doi: 10.7717/peerj.12926. eCollection 2022.
2
On an unbiased and consistent estimator for mutation rates.一种无偏且一致的突变率估计量。
J Theor Biol. 2012 May 7;300:360-7. doi: 10.1016/j.jtbi.2012.01.029. Epub 2012 Feb 8.
3
Genetic Variability Under the Seedbank Coalescent.种子库溯祖模型下的遗传变异性
Genetics. 2015 Jul;200(3):921-34. doi: 10.1534/genetics.115.176818. Epub 2015 May 7.
4
Towards improvements in the estimation of the coalescent: implications for the most effective use of Y chromosome short tandem repeat mutation rates.为了改进融合估计：对最有效地利用 Y 染色体短串联重复突变率的影响。
PLoS One. 2012;7(10):e48638. doi: 10.1371/journal.pone.0048638. Epub 2012 Oct 31.
5
Human mutation rate associated with DNA replication timing.与DNA复制时间相关的人类突变率。
Nat Genet. 2009 Apr;41(4):393-5. doi: 10.1038/ng.363. Epub 2009 Mar 15.
6
Sequence diversity under the multispecies coalescent with Yule process and constant population size.在具有尤尔过程和恒定种群大小的多物种溯祖模型下的序列多样性。
Theor Popul Biol. 2012 Mar;81(2):97-101. doi: 10.1016/j.tpb.2011.12.007. Epub 2011 Dec 21.
7
Neutral diversity in experimental metapopulations.实验性集合种群中的中性多样性。
Theor Popul Biol. 2024 Aug;158:89-108. doi: 10.1016/j.tpb.2024.02.011. Epub 2024 Mar 15.
8
Haplotype diversity and SNP frequency dependence in the description of genetic variation.遗传变异描述中的单倍型多样性和单核苷酸多态性频率依赖性。
Eur J Hum Genet. 2004 Jun;12(6):469-77. doi: 10.1038/sj.ejhg.5201179.
9
A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data.全基因组癌症数据中特定部位中性体细胞突变率的模型和分析。
BMC Bioinformatics. 2018 Apr 19;19(1):147. doi: 10.1186/s12859-018-2141-2.
10
Estimating effective population size or mutation rate using the frequencies of mutations of various classes in a sample of DNA sequences.利用DNA序列样本中各类突变的频率来估计有效种群大小或突变率。
Genetics. 1994 Dec;138(4):1375-86. doi: 10.1093/genetics/138.4.1375.

本文引用的文献

1
Spatial structure facilitates the accumulation and persistence of antibiotic-resistant mutants in biofilms.空间结构有助于生物膜中抗生素抗性突变体的积累和持续存在。
Evol Appl. 2018 Dec 22;12(3):498-507. doi: 10.1111/eva.12728. eCollection 2019 Mar.
2
Genetic Variability Under the Seedbank Coalescent.种子库溯祖模型下的遗传变异性
Genetics. 2015 Jul;200(3):921-34. doi: 10.1534/genetics.115.176818. Epub 2015 May 7.
3
Mechanisms of stationary-phase mutagenesis in bacteria: mutational processes in pseudomonads.细菌的静止期诱变机制：假单胞菌中的突变过程。
FEMS Microbiol Lett. 2010 Nov;312(1):1-14. doi: 10.1111/j.1574-6968.2010.02027.x. Epub 2010 Jun 21.
4
Spontaneous Mutation in Non-Dividing Bacteria.非分裂细菌中的自发突变。
Genetics. 1955 Sep;40(5):726-38. doi: 10.1093/genetics/40.5.726.
5
On the meaning and existence of an effective population size.关于有效种群大小的意义与存在
Genetics. 2005 Feb;169(2):1061-70. doi: 10.1534/genetics.104.026799. Epub 2004 Oct 16.
6
Mutation rates in mammalian genomes.哺乳动物基因组中的突变率。
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):803-8. doi: 10.1073/pnas.022629899. Epub 2002 Jan 15.