Nanobiotechnology Department, Faculty of innovative Science and Technology, Razi University, Kermanshah, Iran.
Department of Biological Sciences, Faculty of Science, University of Kurdistan, Sanandaj, Iran.
Expert Rev Anti Infect Ther. 2022 Jun;20(6):897-906. doi: 10.1080/14787210.2022.2045194. Epub 2022 Feb 22.
Mitigation of infectious diseases resulted from antibiotic-resistant bacteria is difficult by current antibiotics. Metal and metal oxide nanoparticles specifically Ag nanoparticles can be efficient antibacterial agents considering their biocompatibility. In this way, biosynthesis of Ag nanoparticles by living organisms or their metabolites has obtained more attention compared to chemical or physical methods.
Bacteria and fungi in extracellular and intracellular pathways and related primary and secondary metabolites can synthesize Ag nanoparticles with synergistic antibacterial activity against bacterial pathogens.
Bacteriostatic and bactericidal effects of these nanoparticles can lead by production of reactive oxygen species and inactivation of biological macromolecules such as proteins and nucleic acids. The present review has tried to discuss recent progress and challenges about biosynthesis mechanisms and antibacterial activity of Ag nanoparticles bio-inspired by archaebacteria, actinomycetes, cyanobacteria, and fungi.
目前的抗生素很难缓解由抗生素耐药菌引起的传染病。考虑到其生物相容性，金属和金属氧化物纳米颗粒，特别是银纳米颗粒，可以作为有效的抗菌剂。通过生物体或其代谢物生物合成银纳米颗粒的方法比化学或物理方法受到了更多的关注。
细胞外和细胞内途径中的细菌和真菌以及相关的初级和次级代谢物可以合成具有协同抗菌活性的银纳米颗粒，对抗细菌病原体。
这些纳米颗粒的抑菌和杀菌作用可以通过产生活性氧和使蛋白质和核酸等生物大分子失活来实现。本综述试图讨论古细菌、放线菌、蓝细菌和真菌生物启发的银纳米颗粒的生物合成机制和抗菌活性的最新进展和挑战。
