Biogenic synthesis of dopamine/carboxymethyl cellulose/TiO nanoparticles using Psidium guajava leaf extract with enhanced antimicrobial and anticancer activities.

The green synthesis of metal oxide nanoparticles (NPs) has garnered considerable attention from researchers due to its utilization of eco-friendly solvents during synthesis and cost-effective approaches. This study focuses on the synthesis of titanium oxide (TiO) and dopamine (DA) carboxymethyl cellulose (CMC)-doped TiO (DA/CMC/TiO) NP using Psidium guajava leaf extract, while also investigating the structural, optical, and morphological and biocidal potential of the prepared NPs. Significantly larger zones of inhibition were observed for DA/CMC/TiO NPs compared to TiO against various pathogens. Moreover, the MTT assay was carried out to evaluate the anticancer activity of the prepared samples against MG-63 cells, and the results revealed that DA/CMC/TiO NPs exhibited significantly higher level of anticancer activity compared to TiO. The experimental results demonstrated that DA/CMC/TiO NPs exhibited enhanced anticancer activity in a dose-dependent manner when compared to TiO NPs.