Sunamoto J, Iwamoto K
Crit Rev Ther Drug Carrier Syst. 1986;2(2):117-36.
Saccharides on the surface of cell membranes play an important role in cell-cell recognition, which is the most important process utilizable for targeting of drugs encapsulated in an artificial cell, liposome. To design a targetable drug carrier, hence, employing synthesized or natural glycolipids as the recognition site of the liposomal drug carrier is certainly one of useful approach. On the other hand, coating the outermost surface of liposomes with polysaccharide derivatives is also another way for liposomes to be utilized as a targetable drug carrier. In this review, from such a viewpoint, the importance and usefulness of saccharide moiety on the surface of liposomes will be discussed in conjunction with the targeting of drugs.
细胞膜表面的糖类在细胞间识别中发挥着重要作用，而细胞间识别是将包裹在人工细胞（脂质体）中的药物靶向输送的最重要过程。因此，为了设计一种可靶向的药物载体，采用合成或天然糖脂作为脂质体药物载体的识别位点无疑是一种有用的方法。另一方面，用多糖衍生物包覆脂质体的最外层表面也是将脂质体用作可靶向药物载体的另一种方式。在这篇综述中，将从这样的观点出发，结合药物靶向性来讨论脂质体表面糖部分的重要性和实用性。
