Etoposide (VP-16-213) and cis-dichlorodiammineplatinum (DDP) in advanced breast carcinoma resistant to previous chemotherapy.

The combination of etoposide (VP-16-213) and cis-dichlorodiammineplatinum (DDP) was evaluated in 23 patients with advanced metastatic breast carcinoma who had not responded to or who had relapsed after previous two-arm chemotherapy (CMF and AV). Nineteen patients were evaluable for efficacy and one of them attained objective response. Stability of the disease was observed in 6 patients.