mTOR 信号级联：HLA 和非 HLA 抗体介导的血管病中的新临床意义？
mTOR signaling cascade: novel clinical implications in HLA and non-HLA antibody-mediated vasculopathies?
机构信息
Paris Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unite de Mixte Recherche S970, Université de Paris, Paris, France; Kidney Transplant Department, Saint Louis Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Paris Translational Research Center for Organ Transplantation, Institut National de la Santé et de la Recherche Médicale, Unite de Mixte Recherche S970, Université de Paris, Paris, France; Kidney Transplant Department, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
出版信息
Kidney Int. 2022 Mar;101(3):451-454. doi: 10.1016/j.kint.2021.12.008.
Antibodies targeting endothelial antigens represent major threats to the integrity of endothelial vasculature, contributing to development of organ transplant rejection and vasculopathies. In this issue, Catar et al. present the mechanisms by which non-human leukocyte antigen angiotensin II type 1 receptor and endothelin-1 type A receptor antibodies mediate impairment of endothelial repair via β2-arrestin link to the mammalian target of rapamycin pathway. This commentary discusses the mechanisms of human leukocyte antigen and non-human leukocyte antigen antibody-endothelium interactions, and the clinical implications and challenges of the use of mammalian target of rapamycin signaling activation as biomarker and therapeutic target in vasculopathies.
针对内皮抗原的抗体是内皮血管完整性的主要威胁，导致器官移植排斥反应和血管病变的发生。在本期中，Catar 等人介绍了非人类白细胞抗原血管紧张素 II 型 1 受体和内皮素-1 型 A 受体抗体通过β2- arrestin 与雷帕霉素靶蛋白途径的联系介导内皮修复损伤的机制。这篇评论讨论了人类白细胞抗原和非人类白细胞抗原抗体-内皮相互作用的机制，以及雷帕霉素靶蛋白信号激活作为血管病变的生物标志物和治疗靶点的临床意义和挑战。
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