Koh Sojung, Park Sangshin
Department of Applied and Computational Mathematics and Statistics, The University of Notre Dame, South Bend, IN, USA.
Graduate School of Urban Public Health & Department of Urban Big Data Convergence, University of Seoul, Seoul, Republic of Korea.
Pediatr Res. 2022 Dec;92(6):1767-1772. doi: 10.1038/s41390-022-01982-4. Epub 2022 Feb 21.
The objective of this study was to determine the association between water and plasma fluoride and blood pressure (BP) among children and adolescents.
Our study population was individuals of 8-18 years in the 2013-2016 National Health and Nutrition Examination Survey. We performed a multivariable linear and logistic regression analysis to examine the relationship between fluoride and BP.
In a linear regression analysis for systolic BP (SBP) (mm Hg) adjusting for age, sex, race, and poverty, fluoride in water (mg/L) was significant with a coefficient of -0.44 (p = 0.046) among adolescents (12-18 years). Additional adjustments for race, poverty, serum levels of cotinine, and BMI remained significant. While an inverse relationship was found in children (8-11 years), none were significant. Fluoride in plasma was not significant across all ages. The odds ratio of high BP for an increase in water fluoride also was not significant.
Higher concentrations of fluoride in water were associated with low SBP only among adolescents. Fluoride alone cannot be responsible for BP as several biological metabolic processes may influence its physiological effects. Fluoride consumption should be considered in conjunction with these processes.
The high fluoride in drinking water was statistically significantly associated with low systolic BP in children and adolescents. The odds ratio of high BP for an increase in fluoride in drinking water was not significant. Our study contributes to the existing literature by providing individualized data and results on an individual level.
本研究的目的是确定儿童和青少年体内水和血浆氟化物与血压（BP）之间的关联。
我们的研究人群为2013 - 2016年全国健康与营养检查调查中8至18岁的个体。我们进行了多变量线性和逻辑回归分析，以检验氟化物与血压之间的关系。
在对收缩压（SBP）（毫米汞柱）进行年龄、性别、种族和贫困状况调整的线性回归分析中，青少年（12 - 18岁）的水中氟化物（毫克/升）具有显著意义，系数为 -0.44（p = 0.046）。对种族、贫困状况、可替宁血清水平和体重指数进行进一步调整后，结果仍然显著。虽然在儿童（8 - 11岁）中发现了负相关关系，但均无显著意义。血浆中的氟化物在所有年龄段均无显著意义。水氟化物增加导致高血压的优势比也无显著意义。
仅在青少年中，水中较高浓度的氟化物与较低的收缩压相关。仅氟化物本身并不能导致血压变化，因为多种生物代谢过程可能会影响其生理效应。应结合这些过程来考虑氟化物的摄入。
饮用水中高氟化物与儿童和青少年的低收缩压在统计学上具有显著关联。饮用水中氟化物增加导致高血压的优势比无显著意义。我们的研究通过在个体层面提供个性化数据和结果，为现有文献做出了贡献。
