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肾衰灵方通过调控SHH-Gli1信号通路减轻慢性肾脏病肾间质纤维化

Shen-Shuai-Ling Formulation Attenuates Renal Interstitial Fibrosis in Chronic Kidney Disease by Regulating SHH-Gli1 Signaling Pathway.

作者信息

Li Ying, Tu Haitao, Luo Yan, Xiong Weijian, Liu Hong, Xiong Yanying, Zhang Qin, Li Huihui, Gao Xuan

机构信息

Department of Nephrology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China.

Department of Nephrology, The First Clinical Hospital of Guangzhou Medical University, Guangzhou 510405, China.

出版信息

Evid Based Complement Alternat Med. 2022 Feb 12;2022:3754985. doi: 10.1155/2022/3754985. eCollection 2022.

DOI:10.1155/2022/3754985
PMID:35190746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8858066/
Abstract

BACKGROUND

Shen-Shuai-Ling Formulation (SSLF) has apparent effects on improving renal function, delaying the progression of chronic kidney disease (CKD).

METHODS

Fifty male SD rats were randomly divided into 5 groups: Sham group, Model group, SSLF group, CPN group, and C + S group. The morphological changes and the collagen fibers of the rat kidneys were observed by HE staining. The expression of -SMA, Col I, SHH, Gli1, and snail1 was detected by Western blot and qPCR. Then, the cells were divided into the control group, SHH group, and SHH + SSLF serum group.

RESULTS

Compared with the Model group, the fibrosis in SSLF, CPN, and C + S groups was significantly alleviated. And, compared with those in the Model group, the expression of -SMA, Col I, SHH, Gli1, Snail in SSLF, CPN, and C + S groups decreased remarkably.

CONCLUSIONS

SSLF remarkably improves renal function and alleviates renal interstitial fibrosis in UUO rats.

摘要

背景

肾衰灵方对改善肾功能、延缓慢性肾脏病（CKD）进展有明显作用。

方法

将50只雄性SD大鼠随机分为5组：假手术组、模型组、肾衰灵方组、慢性肾盂肾炎组和C+S组。通过HE染色观察大鼠肾脏的形态学变化和胶原纤维。采用蛋白质免疫印迹法和qPCR检测α-SMA、I型胶原、SHH、Gli1和Snail1的表达。然后，将细胞分为对照组、SHH组和SHH+肾衰灵方血清组。

结果

与模型组相比，肾衰灵方组、慢性肾盂肾炎组和C+S组的纤维化明显减轻。并且，与模型组相比，肾衰灵方组、慢性肾盂肾炎组和C+S组中α-SMA、I型胶原、SHH、Gli1、Snail的表达显著降低。

结论

肾衰灵方能显著改善单侧输尿管梗阻（UUO）大鼠的肾功能并减轻肾间质纤维化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/67908d488020/ECAM2022-3754985.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/146a583bf86b/ECAM2022-3754985.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/0a47c69ec279/ECAM2022-3754985.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/b8d0678c1153/ECAM2022-3754985.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/b62162edcfb5/ECAM2022-3754985.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/a734c1d21f07/ECAM2022-3754985.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/fb7f1c3e986f/ECAM2022-3754985.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/d92bb69f4502/ECAM2022-3754985.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/67908d488020/ECAM2022-3754985.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/146a583bf86b/ECAM2022-3754985.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/0a47c69ec279/ECAM2022-3754985.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/b8d0678c1153/ECAM2022-3754985.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/b62162edcfb5/ECAM2022-3754985.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/a734c1d21f07/ECAM2022-3754985.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/fb7f1c3e986f/ECAM2022-3754985.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/d92bb69f4502/ECAM2022-3754985.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8b5/8858066/67908d488020/ECAM2022-3754985.008.jpg

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