Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking, Dongcheng District, Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Hospital, No.1 Shuaifuyuan, Wangfujing Street, 100730, Beijing, China.
Osteoporos Int. 2022 Jul;33(7):1535-1544. doi: 10.1007/s00198-021-06289-4. Epub 2022 Feb 21.
Prolactinoma may reduce bone mineral density (BMD) and increase fracture risk, but its influence on bone microarchitecture remains to be elucidated. The purpose of this study is to evaluate bone microarchitecture parameters by high-resolution peripheral quantitative computed tomography (HR-pQCT) in prolactinoma patients.
31 prolactinoma patients and 62 age- and sex-matched healthy controls in our center were included, and HR-pQCT was used to evaluate their bone microarchitecture at the radius and tibia. Z-scores for bone microarchitecture parameters were calculated based on previously published reference.
After adjusting for height and weight, prolactinoma patients had lower trabecular (- 0.011 mm, p = 0.005) and cortical thickness (- 0.116 mm, p = 0.008) and cortical area (- 6.0 mm2, p = 0.013) at radius, as well as lower trabecular (- 0.014 mm, p = 0.008) and cortical (- 0.122 mm, p = 0.022) thickness at tibia compared with the controls. Patients with higher prolactin level had more severe bone microarchitecture impairments. After adjusting for prolactin level and age, male patients had lower trabecular volumetric BMD (vBMD), trabecular number, trabecular thickness, and cortical porosity at radius, as well as lower trabecular vBMD, trabecular bone volume fraction, trabecular number, and cortical area, and higher trabecular separation at tibia compared with female patients. Z-score for radius vBMD was correlated with Z-score for areal BMD (aBMD) at lumbar and femoral neck, while Z-score for tibia vBMD was correlated with Z-score for lumbar aBMD, and some patients with vBMD Z-score below - 2.0 had aBMD Z-score within normal range.
Peripheral bone microarchitecture was impaired in prolactinoma patients, especially in patients with higher prolactin level. We compared the bone microarchitecture of prolactinoma patients and healthy controls by high-resolution peripheral quantitative computed tomography (HR-pQCT), and found that many bone microarchitecture parameters were impaired among prolactinoma patients. Such impairment was more prominent among patients with higher prolactin level.
催乳素瘤可能会降低骨密度（BMD）并增加骨折风险，但它对骨微结构的影响仍需阐明。本研究的目的是通过高分辨率外周定量计算机断层扫描（HR-pQCT）评估催乳素瘤患者的骨微结构参数。
本研究纳入了我院 31 例催乳素瘤患者和 62 名年龄和性别匹配的健康对照者，并使用 HR-pQCT 评估了他们的桡骨和胫骨骨微结构。根据先前发表的参考值，计算了骨微结构参数的 Z 分数。
调整身高和体重后，与对照组相比，催乳素瘤患者桡骨的骨小梁（-0.011mm，p=0.005）和皮质厚度（-0.116mm，p=0.008）和皮质面积（-6.0mm2，p=0.013）更低，胫骨的骨小梁（-0.014mm，p=0.008）和皮质（-0.122mm，p=0.022）厚度也更低。催乳素水平较高的患者骨微结构损伤更严重。调整催乳素水平和年龄后，与女性患者相比，男性患者桡骨的骨小梁体积 BMD（vBMD）、骨小梁数量、骨小梁厚度和皮质孔隙率更低，胫骨的骨小梁 vBMD、骨小梁体积分数、骨小梁数量和皮质面积更低，骨小梁分离度更高。桡骨 vBMD 的 Z 分数与腰椎和股骨颈的面积 BMD（aBMD）的 Z 分数相关，而胫骨 vBMD 的 Z 分数与腰椎 aBMD 的 Z 分数相关，一些 vBMD Z 分数低于-2.0 的患者的 aBMD Z 分数在正常范围内。
催乳素瘤患者的外周骨微结构受损，尤其是催乳素水平较高的患者。我们通过高分辨率外周定量计算机断层扫描（HR-pQCT）比较了催乳素瘤患者和健康对照者的骨微结构，发现催乳素瘤患者的许多骨微结构参数受损，且催乳素水平较高的患者的骨微结构受损更为明显。
