Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, ChangchunJilin, 130041, China.
Department of Nephrology, Jinan Central Hospital, 105 Jiefang Road, Jinan, 250013, Shandong, China.
Clin Rheumatol. 2022 Jul;41(7):2225-2231. doi: 10.1007/s10067-022-06113-2. Epub 2022 Feb 21.
Psoriasis is a systemic inflammatory disease that is associated with increased risk of several diseases, such as psoriatic arthritis (PsA), inflammatory bowel disease, and cardiovascular diseases. About 20 to 30% patients with psoriasis subsequently develop PsA. IgA nephropathy is the most common primary glomerular disease world-wide. Psoriasis and IgA nephropathy appear to be associated, but the mechanism underlying this connection is unclear. Tofacitinib and leflunomide are common treatments for psoriatic arthritis. We administered tofacitinib combined with leflunomide to a 38-year-old female patient who presented with PsA and IgA nephropathy. After treatment, she experienced significant reductions in the psoriatic lesions, pain in the right knee joint, and proteinuria. Administration of tofacitinib combined with leflunomide for treatment of a patient who had PsA complicated with IgA nephropathy led to significant resolution of the symptoms of both conditions. These results suggest similarities in the pathogenesis of PsA and IgA nephropathy and a possible new treatment for IgA nephropathy.
银屑病是一种系统性炎症性疾病，与多种疾病的风险增加相关，如银屑病关节炎（PsA）、炎症性肠病和心血管疾病。约 20%至 30%的银屑病患者随后会发展为 PsA。IgA 肾病是全球最常见的原发性肾小球疾病。银屑病和 IgA 肾病似乎有关联，但这种关联的机制尚不清楚。托法替尼和来氟米特是治疗银屑病关节炎的常用药物。我们对一名患有 PsA 和 IgA 肾病的 38 岁女性患者联合应用托法替尼和来氟米特进行治疗。治疗后，她的银屑病皮损、右膝关节疼痛和蛋白尿显著减轻。用托法替尼联合来氟米特治疗并发 IgA 肾病的银屑病关节炎患者，两种疾病的症状均显著缓解。这些结果表明，PsA 和 IgA 肾病的发病机制存在相似性，并且可能为 IgA 肾病提供一种新的治疗方法。
