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成人注意力缺陷多动障碍与睡眠障碍:意大利精神科门诊患者样本中睡眠障碍的患病率、严重程度及预测因素

Adult ADHD and sleep disorders: Prevalence, severity and predictors of sleep disorders in a sample of Italian psychiatric outpatients.

作者信息

Valsecchi Paolo, Nibbio Gabriele, Rosa Jennifer, Vita Antonio

机构信息

Department of Clinical and Experimental Sciences, University of Brescia, Piazzale Spedali Civili 1, Brescia 25123, Italy; Department of Mental Health and Addiction Services, Spedali Civili Hospital, Brescia, Italy.

Department of Clinical and Experimental Sciences, University of Brescia, Piazzale Spedali Civili 1, Brescia 25123, Italy; Department of Mental Health and Addiction Services, Spedali Civili Hospital, Brescia, Italy.

出版信息

Psychiatry Res. 2022 Apr;310:114447. doi: 10.1016/j.psychres.2022.114447. Epub 2022 Feb 15.

Abstract

OBJECTIVE

Sleep disorders are frequent in adult subjects diagnosed with ADHD. The aims of the present study were to assess the prevalence and the severity of sleep disorders in a sample of Italian psychiatric outpatients, to compare the prevalence and severity of sleep disorders in patients with and without diagnosis of adult ADHD, and to evaluate the role of ADHD as an individual predictor of sleep disturbances severity.

METHOD

634 outpatients accessing psychiatric services were assessed with the Mini-International Neuropsychiatric Interview (MINI) Plus V. 5.0.0 interview and the Adult ADHD self-report Scale Symptoms Checklist (ASRS)-V 1.1 Short Form. Patients positive to the ASRS-V 1.1 were assessed with the Diagnostic Interview for ADHD in Adults (DIVA) 2.0. Sleep disorders and sleep disturbances' severity were assessed with the PROMIS Adult Sleep Disturbance Scale.

RESULTS

Sleep disorders were more frequent (p < 0.001) and sleep disturbances were more severe (d = 1.26, p < 0.001) in subjects diagnosed with adult ADHD compared to other outpatients. Among the 44 subjects diagnosed with ADHD, 15 (34.1%) reported no or slight sleep disturbances, 9 (20.5%) a mild sleep disorder, 17 (38.6%) a moderate sleep disorder and 3 (6.8%) a severe sleep disorder. ADHD diagnosis, multiple psychiatric comorbidity and history of suicide attempts emerged as individual predictors of worse sleep disturbances.

CONCLUSION

Sleep disorders are more frequent and severe in subjects diagnosed with ADHD compared to other adult outpatients. Sleep disturbances might represent an intrinsic feature in adult ADHD subjects, presenting important clinical repercussions, and should be routinely evaluated and monitored in this population.

摘要

目的

睡眠障碍在被诊断患有注意力缺陷多动障碍(ADHD)的成年患者中很常见。本研究的目的是评估一组意大利精神科门诊患者中睡眠障碍的患病率和严重程度,比较有和没有成人ADHD诊断的患者中睡眠障碍的患病率和严重程度,并评估ADHD作为睡眠障碍严重程度的个体预测因素的作用。

方法

对634名接受精神科服务的门诊患者进行了简明国际神经精神访谈(MINI)Plus V. 5.0.0访谈和成人ADHD自陈量表症状清单(ASRS)-V 1.1简表评估。对ASRS-V 1.1呈阳性的患者用成人ADHD诊断访谈(DIVA)2.0进行评估。用患者报告结果测量信息系统(PROMIS)成人睡眠障碍量表评估睡眠障碍和睡眠干扰的严重程度。

结果

与其他门诊患者相比,被诊断患有成人ADHD的患者睡眠障碍更频繁(p < 0.001),睡眠干扰更严重(d = 1.26,p < 0.001)。在44名被诊断患有ADHD的患者中,15名(34.1%)报告无或有轻微睡眠干扰,9名(20.5%)有轻度睡眠障碍,17名(38.6%)有中度睡眠障碍,3名(6.8%)有重度睡眠障碍。ADHD诊断、多种精神科合并症和自杀未遂史是睡眠干扰更严重的个体预测因素。

结论

与其他成年门诊患者相比,被诊断患有ADHD的患者睡眠障碍更频繁、更严重。睡眠干扰可能是成人ADHD患者的一个内在特征,具有重要的临床影响,因此应对该人群进行常规评估和监测。

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