葡萄糖代谢紊乱加剧由颗粒物空气污染引发的血管功能障碍：一项群组研究。

Glucose Metabolic Disorders Enhance Vascular Dysfunction Triggered by Particulate Air Pollution: a Panel Study.

作者信息

Chen Wu, Han Yiqun, Wang Yanwen, Chen Xi, Qiu Xinghua, Li Weiju, Xu Yifan, Zhu Tong

机构信息

BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Center for Environment and Health (W.C., Y.H., Y.W., X.C., X.Q., Y.X., T.Z.), Peking University, Beijing, China.

Environmental Research Group, MRC Centre for Environment and Health, Imperial College London, United Kingdom (Y.H.).

出版信息

Hypertension. 2022 May;79(5):1079-1090. doi: 10.1161/HYPERTENSIONAHA.121.18889. Epub 2022 Feb 23.

DOI:10.1161/HYPERTENSIONAHA.121.18889

PMID:35193365

Abstract

BACKGROUND

Vascular dysfunction is a biological pathway whereby particulate matter (PM) exerts deleterious cardiovascular effects. The effects of ambient PM on vascular function in prediabetic individuals are unclear.

METHODS

A panel study recruited 112 Beijing residents with and without prediabetes. Multiple vascular function indices were measured up to 7 times. The associations between vascular function indices and short-term exposure to ambient PM, including fine particulate matter (PM), ultrafine particles, accumulation mode particles, and black carbon, and the modification of these associations by glucose metabolic status were examined using linear mixed-effects models.

RESULTS

Increases in brachial artery pulse pressure, central aortic pulse pressure, and ejection duration, and decreases in subendocardial viability ratio and reactive hyperemia index were significantly associated with at least one PM pollutant in all participants, indicating increased vascular dysfunction. For example, for an interquartile range increment in 5-day moving average ultrafine particles, brachial artery pulse pressure, and central aortic pulse pressure increased 5.4% (0.8%-10.4%) and 6.2% (1.2%-11.5%), respectively. Additionally, PM-associated changes in vascular function differed according to glucose metabolic status. Among participants with high fasting blood glucose levels (≥6.1 mmol/L), PM exposure was significantly associated with increased brachial artery systolic blood pressure, central aortic systolic blood pressure, brachial artery pulse pressure, central aortic pulse pressure, and augmentation pressure normalized to a heart rate of 75 bpm and decreased subendocardial viability ratio and reactive hyperemia index. Weaker or null associations were observed in the low-fasting blood glucose group.

CONCLUSIONS

Glucose metabolic disorders may exacerbate vascular dysfunction associated with short-term ambient PM exposure.

摘要

背景

血管功能障碍是颗粒物（PM）产生有害心血管效应的生物学途径。环境PM对糖尿病前期个体血管功能的影响尚不清楚。

方法

一项队列研究招募了112名有或无糖尿病前期的北京居民。多次测量多种血管功能指标，最多测量7次。使用线性混合效应模型研究血管功能指标与短期暴露于环境PM（包括细颗粒物（PM）、超细颗粒物、积聚模态颗粒物和黑碳）之间的关联，以及葡萄糖代谢状态对这些关联的影响。

结果

在所有参与者中，肱动脉脉压、中心主动脉脉压和射血持续时间的增加，以及心内膜下存活比率和反应性充血指数的降低与至少一种PM污染物显著相关，表明血管功能障碍增加。例如，5天移动平均超细颗粒物的四分位数间距增加时，肱动脉脉压和中心主动脉脉压分别增加5.4%（0.8%-10.4%）和6.2%（1.2%-11.5%）。此外，PM相关的血管功能变化因葡萄糖代谢状态而异。在空腹血糖水平高（≥6.1 mmol/L）的参与者中，PM暴露与肱动脉收缩压、中心主动脉收缩压、肱动脉脉压、中心主动脉脉压以及心率为75次/分时的增压显著增加以及心内膜下存活比率和反应性充血指数降低显著相关。在空腹血糖水平低的组中观察到较弱或无关联。