Elhemaly Ahmed, Refaey Osama El, Rizkallah Reda Samuel, Refaat Amal, Zaghloul Mohamed Saad
Department of Pediatric Oncology, National Cancer Institute, Cairo University & Children's Cancer Hospital Egypt (CCHE-57357), Cairo, Egypt.
Department of Pediatric Oncology & Palliative Care, Children's Cancer Hospital Egypt (CCHE-57357), Cairo, Egypt.
Future Oncol. 2022 May;18(16):1943-1950. doi: 10.2217/fon-2021-1455. Epub 2022 Feb 23.
This study aimed to investigate diffuse intrinsic pontine glioma-specific symptoms in the last 12 weeks before death and to describe current palliative care. A retrospective study included 80 pediatric diffuse intrinsic pontine glioma patients diagnosed between January 2018 and December 2019. The most frequently encountered symptoms were headache, gait disturbance, vomiting, dysphagia, sensory loss, seizures and constipation. Steroids were used in 96% of patients with a high success rate, as well as analgesics (67.5%), antiemetics (59%), neuropathic medication (42.5%) and anticonvulsants (37.5%). Re-irradiation improved symptoms in 50% of patients. Steroids were efficient in managing many symptoms, with tolerated side effects. The symptomatic treatment succeeded in relieving end-of-life symptoms. Re-irradiation should be considered a good palliative tool in addition to regular symptomatic treatment.
本研究旨在调查弥漫性脑桥内在型胶质瘤患者在死亡前12周的特异性症状，并描述当前的姑息治疗情况。一项回顾性研究纳入了2018年1月至2019年12月期间确诊的80例儿童弥漫性脑桥内在型胶质瘤患者。最常出现的症状为头痛、步态障碍、呕吐、吞咽困难、感觉丧失、癫痫发作和便秘。96%的患者使用了类固醇，成功率较高，还有67.5%的患者使用了镇痛药、59%的患者使用了止吐药、42.5%的患者使用了治疗神经病变的药物、37.5%的患者使用了抗惊厥药。再次放疗使50%的患者症状得到改善。类固醇在控制多种症状方面有效，且副作用可耐受。对症治疗成功缓解了临终症状。除常规对症治疗外，再次放疗应被视为一种良好的姑息治疗手段。
