Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Taheri Mohammad, Jamali Elena
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Cell Int. 2022 Feb 22;22(1):91. doi: 10.1186/s12935-022-02521-1.
Long non-coding RNAs and microRNAs have recently attained much attention regarding their role in the development of B cell lineage as well as participation in the lymphomagenesis. These transcripts have a highly cell type specific signature which endows them the potential to be used as biomarkers for clinical situations. Aberrant expression of several non-coding RNAs has been linked with B cell malignancies and immune related disorders such as rheumatoid arthritis, systemic lupus erythematous, asthma and graft-versus-host disease. Moreover, these transcripts can alter response of immune system to infectious conditions. miR-7, miR-16-1, miR-15a, miR-150, miR-146a, miR-155, miR-212 and miR-132 are among microRNAs whose role in the development of B cell-associated disorders has been investigated. Similarly, SNHG14, MALAT1, CRNDE, AL133346.1, NEAT1, SMAD5-AS1, OR3A4 and some other long non-coding RNAs participate in this process. In the current review, we describe the role of non-coding RNAs in B cell malignancies.
长链非编码RNA和微小RNA最近在B细胞谱系发育以及淋巴瘤发生过程中的作用备受关注。这些转录本具有高度细胞类型特异性特征，使其有潜力用作临床状况的生物标志物。几种非编码RNA的异常表达与B细胞恶性肿瘤以及免疫相关疾病如类风湿性关节炎、系统性红斑狼疮、哮喘和移植物抗宿主病有关。此外，这些转录本可改变免疫系统对感染状况的反应。miR-7、miR-16-1、miR-15a、miR-150、miR-146a、miR-155、miR-212和miR-132等微小RNA在B细胞相关疾病发生过程中的作用已得到研究。同样，SNHG14、MALAT1、CRNDE、AL133346.1、NEAT1、SMAD5-AS1、OR3A4和其他一些长链非编码RNA也参与这一过程。在本综述中，我们描述了非编码RNA在B细胞恶性肿瘤中的作用。
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