非编码RNA在垂体瘤和脑膜瘤中的新兴作用
The Emerging Role of Non-Coding RNAs in Pituitary Gland Tumors and Meningioma.
作者信息
Ghafouri-Fard Soudeh, Abak Atefe, Hussen Bashdar Mahmud, Taheri Mohammad, Sharifi Guive
机构信息
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran 19835-35511, Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran 19835-35511, Iran.
出版信息
Cancers (Basel). 2021 Nov 28;13(23):5987. doi: 10.3390/cancers13235987.
Long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are non-coding transcripts which are involved in the pathogenesis of pituitary gland tumors. LncRNAs that participate in the pathogenesis of pituitary gland tumors mainly serve as sponges for miRNAs. CLRN1-AS1/miR-217, XIST/miR-424-5p, H19/miR-93a, LINC00473/miR-502-3p, SNHG7/miR-449a, MEG8/miR-454-3p, MEG3/miR-23b-3p, MEG3/miR-376B-3P, SNHG6/miR-944, PCAT6/miR-139-3p, lncRNA-m433s1/miR-433, TUG1/miR-187-3p, SNHG1/miR-187-3p, SNHG1/miR-302, SNHG1/miR-372, SNHG1/miR-373, and SNHG1/miR-520 are identified lncRNA/miRNA pairs that are involved in this process. Hsa_circ_0001368 and circOMA1 are two examples of circRNAs that contribute to the pathogenesis of pituitary gland tumors. Meanwhile, SNHG1, LINC00702, LINC00460, and MEG3 have been found to partake in the pathogenesis of meningioma. In the current review, we describe the role of non-coding RNAs in two types of brain tumors, i.e., pituitary tumors and meningioma.
长链非编码RNA（lncRNAs）、微小RNA（miRNAs）和环状RNA（circRNAs）是非编码转录本，它们参与垂体瘤的发病机制。参与垂体瘤发病机制的lncRNAs主要作为miRNAs的海绵。CLRN1-AS1/miR-217、XIST/miR-424-5p、H19/miR-93a、LINC00473/miR-502-3p、SNHG7/miR-449a、MEG8/miR-454-3p、MEG3/miR-23b-3p、MEG3/miR-376B-3P、SNHG6/miR-944、PCAT6/miR-139-3p、lncRNA-m433s1/miR-433、TUG1/miR-187-3p、SNHG1/miR-187-3p、SNHG1/miR-302、SNHG1/miR-372、SNHG1/miR-373和SNHG1/miR-520是已确定的参与此过程的lncRNA/miRNA对。Hsa_circ_0001368和circOMA1是有助于垂体瘤发病机制的circRNAs的两个例子。同时，已发现SNHG1、LINC00702、LINC00460和MEG3参与脑膜瘤的发病机制。在本综述中，我们描述了非编码RNA在两种脑肿瘤即垂体瘤和脑膜瘤中的作用。
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