Institute of Maternal and Child Health, Government Medical College, Calicut, Kerala. Correspondence to: Dr RV Hridya, Senior Resident, Department of Pediatrics, Government Medical College, Calicut, Kerala.
Institute of Maternal and Child Health, Government Medical College, Calicut, Kerala.
Indian Pediatr. 2022 Feb 15;59(2):114-116.
To study the efficacy and adverse effects of opioids in management of pain in children.
A descriptive study was conducted in children aged below 15 years with moderate to severe pain, and response to opioids and adverse effects were assessed at 24, 48 and 72 hours after administration.
100 children (68% males) with median (IQR) age of 6.5 (3.5,10) years were studied. 81% (n=81) children with moderate pain and 78.9% (n=15) with severe pain responded to opioids in 72 hours. Among children with severe pain of non-malignant origin, 80% (n=8) responded in 48 hours compared to 11.1% (n=1) with malignancy and this difference was statistically significant at 24 hours (P=0.005). Of children with severe pain 73.7% (n=14) developed adverse reactions compared to 30.9% (n=25) with moderate pain.
Children with moderate-severe pain, either of malignant or non-malignant origin could be managed effectively with opioids without severe adverse effects.
研究阿片类药物在儿童疼痛管理中的疗效和不良反应。
对年龄在 15 岁以下、有中重度疼痛的儿童进行描述性研究，在给药后 24、48 和 72 小时评估阿片类药物的反应和不良反应。
共研究了 100 名（68%为男性）年龄中位数（IQR）为 6.5（3.5，10）岁的儿童。81%（n=81）有中度疼痛的儿童和 78.9%（n=15）有重度疼痛的儿童在 72 小时内对阿片类药物有反应。在非恶性来源的重度疼痛儿童中，80%（n=8）在 48 小时内有反应，而恶性来源的儿童仅有 11.1%（n=1）有反应，这在 24 小时时差异有统计学意义（P=0.005）。有重度疼痛的儿童中，73.7%（n=14）出现不良反应，而中度疼痛的儿童中，这一比例为 30.9%（n=25）。
无论疼痛是恶性还是非恶性来源，中重度疼痛的儿童都可以用阿片类药物有效治疗，且不会出现严重不良反应。
