Koch C, Behrendt N
Immunogenetics. 1986;23(5):322-5. doi: 10.1007/BF00398796.
A mouse monoclonal antibody, HAV 4-1, obtained after immunization of a BALB/c mouse with purified C3F, detected a novel genetic polymorphism of human complement component C3 in a simple immunoblotting system. The frequency of HAV 4-1-positive genes was 20.1%. Reactivity of HAV 4-1 was closely related to C3F, but certain individuals with the C3F allele did not react with HAV 4-1. Conversely, certain C3S homozygous individuals did react with HAV 4-1. The polymorphism detected by this monoclonal antibody is therefore different from the previously described polymorphism based on charge differences.
用纯化的C3F免疫BALB/c小鼠后获得的一种小鼠单克隆抗体HAV 4-1，在一个简单的免疫印迹系统中检测到人类补体成分C3的一种新的基因多态性。HAV 4-1阳性基因的频率为20.1%。HAV 4-1的反应性与C3F密切相关，但某些具有C3F等位基因的个体不与HAV 4-1反应。相反，某些C3S纯合个体确实与HAV 4-1反应。因此，这种单克隆抗体检测到的多态性与先前基于电荷差异描述的多态性不同。
