Crafts Trevor D, Tonneson Jennifer E, Wolfe Bruce M, Stroud Andrea M
Department of Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Obesity (Silver Spring). 2022 Mar;30(3):587-598. doi: 10.1002/oby.23369.
Breast cancer is the most common and second deadliest malignancy in women. With rising obesity rates and building evidence for a strong association with obesity, the incidence of breast cancer can be expected to increase. Weight loss reduces breast cancer risk, the mechanisms of which are still poorly understood. As an effective therapy for obesity, bariatric surgery may be a powerful tool in breast cancer prevention and treatment. This review details the potential physiologic mechanisms that may underlie this association, as well as recently published studies that reinforce the link between bariatric surgery and a reduction in incident breast cancer. The use of bariatric surgery as an adjunct therapy in endometrial cancer also raises the potential for similar use in select breast cancer patients. Despite the expanding potential applications of bariatric surgery in this field, publications to date have been strictly observational, highlighting a need for future clinical trials.
乳腺癌是女性中最常见且致死率第二高的恶性肿瘤。随着肥胖率的上升以及越来越多证据表明肥胖与之存在紧密关联，预计乳腺癌的发病率将会增加。体重减轻可降低乳腺癌风险，但其机制仍知之甚少。作为一种治疗肥胖的有效方法，减肥手术可能是预防和治疗乳腺癌的有力工具。这篇综述详细阐述了可能构成这种关联基础的潜在生理机制，以及最近发表的加强减肥手术与乳腺癌发病率降低之间联系的研究。将减肥手术用作子宫内膜癌的辅助治疗也增加了在特定乳腺癌患者中类似应用的可能性。尽管减肥手术在该领域的潜在应用不断扩大，但迄今为止的出版物均为严格的观察性研究，这凸显了未来进行临床试验的必要性。
