Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia.
J Exp Med. 2022 Mar 7;219(3). doi: 10.1084/jem.20211604. Epub 2022 Feb 23.
Leukocyte trafficking between blood and tissues is an essential function of the immune system that facilitates humoral and cellular immune responses. Within tissues, leukocytes perform surveillance and effector functions via cell motility and migration toward sites of tissue damage, infection, or inflammation. Neurotransmitters that are produced by the nervous system influence leukocyte trafficking around the body and the interstitial migration of immune cells in tissues. Neural regulation of leukocyte dynamics is influenced by circadian rhythms and altered by stress and disease. This review examines current knowledge of neuro-immune interactions that regulate leukocyte migration and consequences for protective immunity against infections and cancer.
白细胞在血液和组织间的迁移是免疫系统的一项基本功能，有助于体液免疫和细胞免疫应答。在组织内，白细胞通过细胞运动和向组织损伤、感染或炎症部位迁移来执行监视和效应功能。神经系统产生的神经递质影响全身白细胞的迁移和组织中免疫细胞的间质迁移。白细胞动力学的神经调节受昼夜节律的影响，并受应激和疾病的改变。这篇综述检查了调节白细胞迁移的神经免疫相互作用的现有知识及其对抗感染和抗癌的保护性免疫的影响。
