State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Med-X Center for Materials, Sichuan University, Chengdu, China.
DNA Cell Biol. 2022 Mar;41(3):276-284. doi: 10.1089/dna.2021.0869. Epub 2022 Feb 23.
Bone marrow-derived mesenchymal stem cell (BMSC)-based and macrophage-based cell therapy are regarded as promising strategies to promote fracture healing because of incredible osteogenic potential of BMSCs and typical immunomodulatory function of macrophages. Apart from their respective key roles, accumulative evidence has also demonstrated the importance of cross talk between these two cell types in fracture healing process. This review takes a deep insight into the recent research progress of the synergic performance of BMSCs and macrophages by discussing not only the cells own functions but also the relevant impact factors and mechanisms (ambient microenvironment stimulus, miRNAs, etc). The aim of this review is to provide some valuable cues and technique support for the macrophage- and BMSC-related research, which will be helpful to propel BMSC/macrophage-based combined cell therapy for bone fracture treatment.
基于骨髓间充质干细胞（BMSC）和巨噬细胞的细胞疗法被认为是促进骨折愈合的有前途的策略，因为 BMSC 具有令人难以置信的成骨潜力，巨噬细胞具有典型的免疫调节功能。除了各自的关键作用外，累积的证据还表明这两种细胞类型之间的交流在骨折愈合过程中的重要性。通过讨论细胞自身的功能以及相关的影响因素和机制（环境微环境刺激、miRNAs 等），本综述深入探讨了 BMSC 和巨噬细胞协同作用的最新研究进展。本综述的目的是为巨噬细胞和 BMSC 相关研究提供一些有价值的线索和技术支持，这将有助于推动基于 BMSC/巨噬细胞的联合细胞疗法治疗骨骨折。
