神经内分泌肿瘤患者中的烯醇化酶亚基。

Enolase subunits in patients with neuroendocrine tumors.

作者信息

Iwase K, Nagasaka A, Kato K, Ohtani S, Nagatsu I, Ohyama T, Nakai A, Aono T, Nakagawa H, Shinoda S

出版信息

J Clin Endocrinol Metab. 1986 Jul;63(1):94-101. doi: 10.1210/jcem-63-1-94.

PMID:3519652

Abstract

Concentrations of the alpha-, beta-, and gamma-subunits of enolase in surgically resected tumors and serum obtained from patients with various endocrine tumors were measured by a sensitive enzyme immunoassay system. Tissue concentrations of the gamma-subunit were significantly elevated in patients with neuroendocrine tumors concurrent with high concentrations of the gamma-subunit in their serum, which fell to normal in 90% of those who underwent tumor resection. Immunohistochemical analysis revealed that considerable amounts of the gamma-subunit were contained specifically in these tumors. These results indicate that the gamma-subunit of enolase is a useful marker for diagnosing and monitoring patients with neuroendocrine tumors.

摘要

采用灵敏的酶免疫分析系统，对手术切除的肿瘤组织以及从患有各种内分泌肿瘤的患者体内获取的血清中烯醇化酶的α、β和γ亚基浓度进行了测定。神经内分泌肿瘤患者的肿瘤组织中γ亚基浓度显著升高，同时其血清中γ亚基浓度也很高，在90%接受肿瘤切除的患者中，该浓度降至正常水平。免疫组织化学分析显示，这些肿瘤中特异性地含有大量的γ亚基。这些结果表明，烯醇化酶的γ亚基是诊断和监测神经内分泌肿瘤患者的有用标志物。