哌甲酯对注意力缺陷多动障碍儿童及青少年生长发育的24个月影响
A 24-Month Effects of Methylphenidate Use on Growth in Children and Adolescents With Attention Deficit Hyperactivity Disorder.
作者信息
Lee Yoojeong, Kong Nayeong, Koo San, Bai Dai Seg, Kim Hee Jin, Jeong Hyunseok, Seo Wan Seok
机构信息
Department of Psychiatry, Yeungnam University Hospital, Daegu, Republic of Korea.
Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
出版信息
Psychiatry Investig. 2022 Mar;19(3):213-219. doi: 10.30773/pi.2021.0309. Epub 2022 Feb 25.
OBJECTIVE
The primary objective of this study was to investigate the effect of methylphenidate (MPH) on height, weight, and body mass index (BMI) in drug-naive children and adolescents with attention deficit hyperactivity disorder (ADHD) over 24 months. The secondary objective was to investigate whether the age of MPH initiation and sex act as risk factors for growth retardation.
METHODS
A total of 82 patients with ADHD were included. Weight, height, and BMI were measured at baseline and every 6 months up to 24 months. Weight, height, and BMI data were converted to z-scores and analyzed using two-way repeated-measures ANOVA and multiple linear regression.
RESULTS
The z-score of height, weight and BMI decreased from the baseline values. The z-scores of height were at baseline 0.002; 6 months -0.100; 12 months -0.159; 18 months -0.159; 24 months -0.186. The z-scores of weight were at baseline 0.104; 6 months -0.155; 12 months -0.256; 18 months -0.278; 24 months -0.301. Here were no age and sex differences of height, weight, and BMI.
CONCLUSION
The use of MPH was associated with attenuation of weight and height gain rates in children and adolescents with ADHD.
目的
本研究的主要目的是调查哌甲酯（MPH）对初治注意力缺陷多动障碍（ADHD）儿童和青少年24个月期间身高、体重和体重指数（BMI）的影响。次要目的是调查开始使用MPH的年龄和性别是否为生长发育迟缓的危险因素。
方法
共纳入82例ADHD患者。在基线时以及直至24个月期间每6个月测量一次体重、身高和BMI。将体重、身高和BMI数据转换为z分数，并使用双向重复测量方差分析和多元线性回归进行分析。
结果
身高、体重和BMI的z分数从基线值下降。身高的z分数在基线时为0.002；6个月时为-0.100；12个月时为-0.159；18个月时为-0.159；24个月时为-0.186。体重的z分数在基线时为0.104；6个月时为-0.155；12个月时为-0.256；18个月时为-0.278；24个月时为-0.301。身高、体重和BMI在年龄和性别方面无差异。
结论
在患有ADHD的儿童和青少年中，使用MPH与体重和身高增长率的降低有关。
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