534329Iladevi Cataract and IOL Research Centre, Memnagar, Ahmedabad, Gujarat, India.
76793Manipal Academy of Higher Education, Mangalore, Karnataka, India.
Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211063165. doi: 10.1177/09603271211063165.
AMP-activated protein kinase (AMPK) plays a precise role as a master regulator of cellular energy homeostasis. AMPK is activated in response to the signalling cues that exhaust cellular ATP levels such as hypoxia, ischaemia, glucose depletion and heat shock. As a central regulator of both lipid and glucose metabolism, AMPK is considered to be a potential therapeutic target for the treatment of various diseases, including eye disorders.
To review all the shreds of evidence concerning the role of the AMPK signalling pathway in the pathogenesis of ocular diseases.
Scientific data search and review of available information evaluating the influence of AMPK signalling on ocular diseases.
Review highlights the significance of AMPK signalling in the aetiopathogenesis of ocular diseases, including cataract, glaucoma, diabetic retinopathy, retinoblastoma, age-related macular degeneration, corneal diseases, etc. The review also provides the information on the AMPK-associated pathways with reference to ocular disease, which includes mitochondrial biogenesis, autophagy and regulation of inflammatory response.
The study concludes the role of AMPK in ocular diseases. There is growing interest in the therapeutic utilization of the AMPK pathway for ocular disease treatment. Furthermore, inhibition of AMPK signalling might represent more pertinent strategy than AMPK activation for ocular disease treatment. Such information will guide the development of more effective AMPK modulators for ocular diseases.[Formula: see text].
AMP 激活的蛋白激酶 (AMPK) 作为细胞能量平衡的精确调控因子发挥作用。AMPK 会在细胞 ATP 水平下降时被激活，例如缺氧、缺血、葡萄糖耗竭和热休克等情况。作为脂质和葡萄糖代谢的中枢调节因子，AMPK 被认为是治疗各种疾病（包括眼部疾病）的潜在治疗靶点。
综述 AMPK 信号通路在眼部疾病发病机制中的作用的所有证据。
对评估 AMPK 信号对眼部疾病影响的可用信息进行科学数据搜索和综述。
综述强调了 AMPK 信号在眼部疾病发病机制中的重要性，包括白内障、青光眼、糖尿病视网膜病变、视网膜母细胞瘤、年龄相关性黄斑变性、角膜疾病等。该综述还提供了与眼部疾病相关的 AMPK 相关途径的信息，包括线粒体生物发生、自噬和炎症反应调节。
本研究总结了 AMPK 在眼部疾病中的作用。人们对 AMPK 通路在眼部疾病治疗中的治疗应用越来越感兴趣。此外，抑制 AMPK 信号可能比 AMPK 激活更适合眼部疾病治疗。这些信息将指导开发更有效的眼部疾病 AMPK 调节剂。
