Department of Obstetrics and Gynecology, Daejeon St Mary's Hospital, 65399The Catholic University of Korea, Daejeon, South Korea.
Department of Obstetrics and Gynecology, St Vincent's Hospital, 65645The Catholic University of Korea, Suwon, South Korea.
Cancer Control. 2022 Jan-Dec;29:10732748221074530. doi: 10.1177/10732748221074530.
The objective is to investigate the factors that can predict early treatment response in patients receiving concurrent chemoradiotherapy (CCRT) for cervical cancer.
We assessed clinical factors and treatment response in patients who underwent CCRT for cervical cancer at four time points: initial, 2.5 weeks, 6 weeks after starting CCRT, and 3 months after completing CCRT. The final treatment response was determined by positron emission tomography-computed tomography (PET-CT) 3 months after completion of CCRT. Patients were divided into two groups according to the final treatment response: complete response (CR) group or non-CR group. And the early CCRT response prediction model was developed using stepwise multivariate logistic regression analysis.
Of the 62 patients who underwent CCRT for cervical cancer, 57 patients who completed all 4 time points examinations were included in the analyses and classified as CR (n = 32) and non-CR (n = 25) group. Tumor volume and serum squamous cell carcinoma antigen (SCC Ag) of the initial, 2.5 weeks, and 6 weeks after CCRT were significantly associated with the final treatment response. For the early treatment response prediction model, we selected patient age, tumor volume, and SCC Ag measured at initial and 2.5 weeks of CCRT as variables, and the equation of the final model was yielded. Using a cutoff of 0.433, this model had a sensitivity of 72.0%, a specificity of 84.4%, and a probability of 0.8225 ( < .0001).
Short-term (at 2.5 weeks after starting CCRT) measurements of tumor volume and serum SCC Ag were significant predictors of response to CCRT in patients with cervical cancer.
旨在探讨接受同期放化疗（CCRT）的宫颈癌患者早期治疗反应的预测因素。
我们评估了在四个时间点（初始、CCRT 开始后 2.5 周、6 周和 CCRT 完成后 3 个月）接受 CCRT 的宫颈癌患者的临床因素和治疗反应。最终的治疗反应由 CCRT 完成后 3 个月的正电子发射断层扫描-计算机断层扫描（PET-CT）确定。根据最终治疗反应将患者分为完全缓解（CR）组和非 CR 组。使用逐步多变量逻辑回归分析建立早期 CCRT 反应预测模型。
在 62 例接受 CCRT 的宫颈癌患者中，有 57 例完成了所有 4 个时间点的检查，并被纳入分析，分为 CR（n=32）和非 CR（n=25）组。CCRT 初始、2.5 周和 6 周时的肿瘤体积和血清鳞状细胞癌抗原（SCCAg）与最终治疗反应显著相关。对于早期治疗反应预测模型，我们选择患者年龄、CCRT 初始和 2.5 周时的肿瘤体积和 SCCAg 作为变量，并得出最终模型的方程。使用 0.433 的截断值，该模型的敏感性为 72.0%，特异性为 84.4%，概率为 0.8225（<0.0001）。
短期（CCRT 开始后 2.5 周）测量肿瘤体积和血清 SCCAg 是宫颈癌患者对 CCRT 反应的显著预测因素。
