Al Jazzar Ragad I, Algarni Mohammed, Al-Maiman Sarah, Alzahrani Nayef
College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
King Saud bin Abdulaziz University for Health Sciences, Oncology Department, Ministry of National Guard-Health Affairs, Saudi Arabia, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
J Surg Case Rep. 2022 Feb 19;2022(2):rjac041. doi: 10.1093/jscr/rjac041. eCollection 2022 Feb.
Treatment of metastatic colorectal cancer has evolved throughout the years and various methods have been proposed to reach a pathological complete response state. We report a case of a 73-year-old male presented with a sigmoid adenocarcinoma with two synchronous liver metastases. The patient received five cycles of FOLFOX neoadjuvant chemotherapy, 41% reduction of tumor size was noted upon reassessment. Therefore, a low anterior resection of the rectum and synchronous resection of segment 5 and 8 of the liver was done along with right-sided diaphragmatic stripping. A pathological complete response was achieved in both primary and secondary tumors that are considered rare and challenging in metastatic colorectal cancer Neoadjuvant chemotherapy showed promising findings in advanced colorectal cancer.
多年来，转移性结直肠癌的治疗方法不断发展，人们提出了各种方法以达到病理完全缓解状态。我们报告一例73岁男性患者，其患有乙状结肠癌并伴有两个同时性肝转移瘤。该患者接受了5个周期的FOLFOX新辅助化疗，重新评估时发现肿瘤大小缩小了41%。因此，进行了直肠低位前切除术以及肝脏5段和8段的同步切除术，并进行了右侧膈肌剥脱术。原发肿瘤和继发肿瘤均实现了病理完全缓解，这在转移性结直肠癌中被认为是罕见且具有挑战性的。新辅助化疗在晚期结直肠癌中显示出了有前景的结果。
