ECT-Resistant Bipolar Depression Treated with a Single Course of Triple Chronotherapy.

The combination of sleep deprivation, sleep phase advance, and bright light is termed triple chronotherapy (TCT). TCT is a promising treatment for depression, but it is not clear how effective it is for depression resistant to conventional treatments such as medications. Here, we report a case of triple chronotherapy effectively treating depression resistant to both medication and an extended course of bilateral electroconvulsive therapy. Triple chronotherapy may be a useful method to consider in cases of severe, treatment-resistant depression.