脂蛋白(a)与肺栓塞严重程度——一项回顾性数据分析
Lipoprotein(a) and Pulmonary Embolism Severity-A Retrospective Data Analysis.
作者信息
Gressenberger Paul, Posch Florian, Pechtold Moritz, Gütl Katharina, Muster Viktoria, Jud Philipp, Riedl Jakob, Silbernagel Günther, Kolesnik Ewald, Schmid Johannes, Raggam Reinhard B, Brodmann Marianne, Gary Thomas
机构信息
Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
出版信息
Front Cardiovasc Med. 2022 Feb 7;9:808605. doi: 10.3389/fcvm.2022.808605. eCollection 2022.
AIM
We aimed to investigate a correlation between PE severity and Lp(a) levels.
METHODS
We performed a retrospective data analysis from our medical records of PE patients admitted to the University Hospital Graz, Austria. Patients with an Lp(a) reading within a 1-year interval before and after PE diagnosis were included. In accordance with the 2019 ESC guidelines for the diagnosis and management of acute PE, severity assessment was carried out classifying patients into four groups: low risk (LR), intermediate low risk (IML), intermediate high risk (IMH) and high risk (HR). The study period of interest was between January 1, 2002 and August 1, 2020.
RESULTS
We analyzed 811 patients with PE, of whom 323 (40%) had low-risk PE, 343 (42%) had intermediate-low-risk PE, 64 (8%) had intermediate-high-risk PE, and 81 (10%) had high-risk PE, respectively. We did not observe an association between PE severity and Lp(a) concentrations. In detail, median Lp(a) concentrations were 17 mg/dL [25-75th percentile: 10-37] in low-risk PE patients, 16 mg/dL [10-37] in intermediate-low-risk PE patients, 15mg/dL [10-48] in intermediate-high-risk PE patients, and 13mg/dL [10-27] in high-risk PE patients, respectively (Kruskal-Wallis = 0.658, p for linear trend = 0.358).
CONCLUSION
The current findings suggest no correlation between PE severity and Lp(a) levels.
目的
我们旨在研究肺栓塞（PE）严重程度与脂蛋白（a）[Lp(a)]水平之间的相关性。
方法
我们对奥地利格拉茨大学医院收治的PE患者的病历进行了回顾性数据分析。纳入在PE诊断前后1年内有Lp(a)读数的患者。根据2019年欧洲心脏病学会（ESC）急性PE诊断和管理指南，对患者进行严重程度评估并分为四组：低风险（LR）、中低风险（IML）、中高风险（IMH）和高风险（HR）。研究时间段为2002年1月1日至2020年8月1日。
结果
我们分析了811例PE患者，其中分别有323例（40%）为低风险PE、343例（42%）为中低风险PE、64例（8%）为中高风险PE和81例（10%）为高风险PE。我们未观察到PE严重程度与Lp(a)浓度之间存在关联。具体而言，低风险PE患者的Lp(a)浓度中位数为17mg/dL[第25 - 75百分位数：10 - 37]，中低风险PE患者为16mg/dL[10 - 37]，中高风险PE患者为15mg/dL[10 - 48]，高风险PE患者为13mg/dL[10 - 27]（Kruskal - Wallis检验=0.658，线性趋势p值=0.358）。
结论
目前的研究结果表明PE严重程度与Lp(a)水平之间无相关性。
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