Chang Diana, Singhal Nilika S, Tarapore Phiroz E, Auguste Kurtis I
University of California, San Francisco, School of Medicine, 533 Parnassus Ave, San Francisco, CA 94143, United States.
University of California, San Francisco, Department of Neurology, 400 Parnassus Ave 8 Floor, San Francisco, CA 94143, United States.
Epilepsy Behav Rep. 2021 Nov 28;18:100511. doi: 10.1016/j.ebr.2021.100511. eCollection 2022.
We present a case of a 10-month-old girl undergoing repetitive TMS (rTMS) for the treatment of drug-resistant epilepsy. A 10-month-old girl, later diagnosed with pathogenic POLG1 mutations, presented to our institution with chronic progressive EPC (epilepsia partialis continua) manifesting as a frequent, left-sided, synchronous continuous jerking of the arms and legs. The seizures were drug-resistant to multiple antiseizure medications and epilepsy surgery, responding only to continuous anesthesia. rTMS therapy was attempted to interrupt seizures. rTMS therapy, using an activating protocol to introduce a temporary lesion effect, was used to interrupt persistent, ongoing seizures. rTMS can be safely used to abort seizures in patients as young as 10 months old.
我们报告一例10个月大的女童接受重复经颅磁刺激（rTMS）治疗耐药性癫痫的病例。一名10个月大的女童，后来被诊断出患有致病性POLG1突变，因慢性进行性部分性持续性癫痫（EPC）就诊于我院，表现为频繁的、左侧的、双侧手臂和腿部同步持续抽搐。这些癫痫发作对多种抗癫痫药物和癫痫手术均耐药，仅对持续麻醉有反应。尝试采用rTMS疗法来中断癫痫发作。使用激活方案引入临时病灶效应的rTMS疗法被用于中断持续性发作。rTMS可安全用于中止年仅10个月大患者的癫痫发作。
