Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, P. R. China.
Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA.
Org Biomol Chem. 2022 Mar 9;20(10):2064-2068. doi: 10.1039/d2ob00186a.
A photocatalytic Smiles rearrangement, triggered by radical difluoromethylation of conjugated arylsulfonylated amides, was developed to construct both β-difluoromethyl amide and heterocyclic scaffolds selectively. This transformation features mild conditions and broad substrate scope. More importantly, the chemoselectivity of the intermediate amidyl radical could be altered completely by simply changing the light source, along with addition of water to the reaction mixture.
一种光催化 Smiles 重排反应，通过共轭芳基磺酰化酰胺的自由基二氟甲基化引发，被开发用于选择性构建β-二氟甲基酰胺和杂环骨架。该转化具有条件温和、底物范围广的特点。更重要的是，通过简单地改变光源，并向反应混合物中加入水，可以完全改变中间体酰基自由基的化学选择性。
