Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden.
EMBO J. 2022 Apr 4;41(7):e110819. doi: 10.15252/embj.2022110819. Epub 2022 Feb 24.
Context-specific control mechanisms of hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in tumors exposed to oxygen shortage remain incompletely understood. In this issue, Zhang et al (2022) identify a deubiquitinase that differentially stabilizes HIF-2alpha in stem-like glioblastoma cells, suggesting potential implications for regulation of the hypoxic response in a wide array of tissues and cancers.
肿瘤在缺氧状态下，缺氧诱导转录因子 HIF-1α 和 HIF-2α 的上下文特异性调控机制仍不完全清楚。在本期杂志中，Zhang 等人（2022 年）发现了一种去泛素化酶，它可使干细胞样脑胶质瘤细胞中的 HIF-2α 产生差异稳定性，这提示其可能对广泛的组织和癌症的低氧反应调控具有潜在意义。
