胰腺星状细胞——胰腺病理学中的后起之秀。
Pancreatic stellate cells - rising stars in pancreatic pathologies.
机构信息
Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic.
出版信息
Physiol Res. 2021 Dec 30;70(Suppl4):S597-S616. doi: 10.33549/physiolres.934783.
Abstract
Pluripotent pancreatic stellate cells (PSCs) receive growing interest in past decades. Two types of PSCs are recognized -vitamin A accumulating quiescent PSCs and activated PSCs- the main producents of extracellular matrix in pancreatic tissue. PSCs plays important role in pathogenesis of pancreatic fibrosis in pancreatic cancer and chronic pancreatitis. PSCs are intensively studied as potential therapeutical target because of their important role in developing desmoplastic stroma in pancreatic cancer. There also exists evidence that PSC are involved in other pathologies like type-2 diabetes mellitus. This article brings brief characteristics of PSCs and recent advances in research of these cells.
摘要
多能性胰腺星状细胞（PSCs）在过去几十年中受到越来越多的关注。目前已经鉴定出两种 PSCs - 维生素 A 蓄积静止 PSCs 和活化 PSCs- 它们是胰腺组织细胞外基质的主要产生者。PSCs 在胰腺癌和慢性胰腺炎的胰腺纤维化发病机制中起重要作用。由于其在胰腺癌中形成纤维性基质中的重要作用，PSCs 作为潜在的治疗靶点受到了广泛研究。也有证据表明 PSCs 参与了其他病理情况，如 2 型糖尿病。本文简要介绍了 PSCs 的特征以及这些细胞研究的最新进展。
相似文献
1
Pancreatic stellate cells - rising stars in pancreatic pathologies.胰腺星状细胞——胰腺病理学中的后起之秀。
Physiol Res. 2021 Dec 30;70(Suppl4):S597-S616. doi: 10.33549/physiolres.934783.
2
Galectin-1 expression in activated pancreatic satellite cells promotes fibrosis in chronic pancreatitis/pancreatic cancer via the TGF-β1/Smad pathway.Galectin-1 在活化的胰腺卫星细胞中的表达通过 TGF-β1/Smad 通路促进慢性胰腺炎/胰腺癌中的纤维化。
Oncol Rep. 2018 Mar;39(3):1347-1355. doi: 10.3892/or.2018.6202. Epub 2018 Jan 9.
3
Roles of pancreatic stellate cells in pancreatic inflammation and fibrosis.胰腺星状细胞在胰腺炎症和纤维化中的作用。
Clin Gastroenterol Hepatol. 2009 Nov;7(11 Suppl):S48-54. doi: 10.1016/j.cgh.2009.07.038.
4
Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.Meflin 是一种胰腺星状细胞标志物，参与胰腺纤维化和上皮再生。
J Pathol. 2024 Jan;262(1):61-75. doi: 10.1002/path.6211. Epub 2023 Oct 5.
5
Pancreatic stellate cell: Pandora's box for pancreatic disease biology.胰腺星状细胞：胰腺疾病生物学的潘多拉魔盒。
World J Gastroenterol. 2017 Jan 21;23(3):382-405. doi: 10.3748/wjg.v23.i3.382.
6
Pancreatic stellate cells: Key players in pancreatic health and diseases (Review).胰腺星状细胞：胰腺健康与疾病的关键因素（综述）。
Mol Med Rep. 2024 Jul;30(1). doi: 10.3892/mmr.2024.13233. Epub 2024 May 2.
7
Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.自噬对于胰腺星状细胞的激活是必需的，与胰腺癌的进展相关，并促进了小鼠胰腺肿瘤的生长。
Gastroenterology. 2017 May;152(6):1492-1506.e24. doi: 10.1053/j.gastro.2017.01.010. Epub 2017 Jan 23.
8
Pancreatic stellate/myofibroblast cells express G-protein-coupled melatonin receptor 1.胰腺星状/肌成纤维细胞表达G蛋白偶联褪黑素受体1。
Wien Med Wochenschr. 2008;158(19-20):575-8. doi: 10.1007/s10354-008-0599-7.
9
Isolation and culture of primary human pancreatic stellate cells that reflect the context of their tissue of origin.反映其起源组织背景的原代人胰腺星状细胞的分离与培养。
Langenbecks Arch Surg. 2016 Feb;401(1):89-97. doi: 10.1007/s00423-015-1343-6. Epub 2015 Dec 29.
10
Connexins regulate cell functions in pancreatic stellate cells.缝隙连接蛋白调节胰腺星状细胞的细胞功能。
Pancreas. 2013 Mar;42(2):308-16. doi: 10.1097/MPA.0b013e31825c51d6.
引用本文的文献
1
Pancreatic extracellular volume fraction based on dual-energy computed tomography iodine maps: association with diabetes.基于双能计算机断层扫描碘图的胰腺细胞外体积分数：与糖尿病的关联
Quant Imaging Med Surg. 2025 Jul 1;15(7):5969-5979. doi: 10.21037/qims-24-2419. Epub 2025 Jun 30.
2
Liver developmental microenvironment promotes iHSC generation from human iPSCs.肝脏发育微环境促进人诱导多能干细胞生成诱导性肝星状细胞。
Sci Rep. 2025 Jul 1;15(1):22338. doi: 10.1038/s41598-025-09026-7.
3
Nanoimmunotherapy: the smart trooper for cancer therapy.纳米免疫疗法：癌症治疗的智能勇士。
Explor Target Antitumor Ther. 2025 Apr 10;6:1002308. doi: 10.37349/etat.2025.1002308. eCollection 2025.
4
PLXDC1 Tumor-Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma.PLXDC1肿瘤相关胰腺星状细胞促进胰腺导管腺癌中的促结缔组织增生和免疫抑制微环境
Adv Sci (Weinh). 2025 May;12(18):e2415756. doi: 10.1002/advs.202415756. Epub 2025 Mar 17.
5
Stellate cells are in utero markers of pancreatic disease in cystic fibrosis.星状细胞是囊性纤维化中胰腺疾病的宫内标志物。
Mol Med. 2024 Aug 7;30(1):115. doi: 10.1186/s10020-024-00871-2.
6
1,25(OH)D inhibits pancreatic stellate cells activation and promotes insulin secretion in T2DM.1,25(OH)D 抑制 T2DM 中胰腺星状细胞的活化并促进胰岛素分泌。
Endocrine. 2024 Sep;85(3):1193-1205. doi: 10.1007/s12020-024-03833-0. Epub 2024 Apr 24.
7
The Clinical Significance and Role of CXCL1 Chemokine in Gastrointestinal Cancers.CXCL1 趋化因子在胃肠道癌中的临床意义和作用。
Cells. 2023 May 17;12(10):1406. doi: 10.3390/cells12101406.
8
The tumor stroma influences immune cell distribution and recruitment in a PDAC-on-a-chip model.肿瘤基质影响 PDAC 芯片模型中免疫细胞的分布和募集。
Front Immunol. 2023 May 2;14:1155085. doi: 10.3389/fimmu.2023.1155085. eCollection 2023.
9
5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In Vitro.5-FU 抑制 miR-15a 通过降低 YAP1 和 BCL-2 水平抑制胰腺星状细胞的活化。
Int J Mol Sci. 2023 Feb 16;24(4):3954. doi: 10.3390/ijms24043954.
10
PAR2: The Cornerstone of Pancreatic Diseases.蛋白酶激活受体 2：胰腺疾病的基石。
Physiol Res. 2022 Nov 28;71(5):583-596. doi: 10.33549/physiolres.934931. Epub 2022 Sep 8.
本文引用的文献
1
Dissecting FGF Signalling to Target Cellular Crosstalk in Pancreatic Cancer.解析 FGF 信号以靶向胰腺癌中的细胞串扰。
Cells. 2021 Apr 8;10(4):847. doi: 10.3390/cells10040847.
2
N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions.N-乙酰半胱氨酸诱导静止样胰腺星状细胞从活跃状态，并减弱癌-基质相互作用。
J Exp Clin Cancer Res. 2021 Apr 15;40(1):133. doi: 10.1186/s13046-021-01939-1.
3
Pancreatic stellate cells regulate branched-chain amino acid metabolism in pancreatic cancer.胰腺星状细胞调节胰腺癌中的支链氨基酸代谢。
Ann Transl Med. 2021 Mar;9(5):417. doi: 10.21037/atm-21-761.
4
Inhibitory Smads suppress pancreatic stellate cell activation through negative feedback in chronic pancreatitis.抑制性Smads通过慢性胰腺炎中的负反馈抑制胰腺星状细胞激活。
Ann Transl Med. 2021 Mar;9(5):384. doi: 10.21037/atm-20-4282.
5
Vitamin A and Its Multi-Effects on Pancreas: Recent Advances and Prospects.维生素 A 及其对胰腺的多效作用：最新进展与展望。
Front Endocrinol (Lausanne). 2021 Feb 18;12:620941. doi: 10.3389/fendo.2021.620941. eCollection 2021.
6
Regulation of Pancreatic Fibrosis by Acinar Cell-Derived Exosomal miR-130a-3p via Targeting of Stellate Cell PPAR-γ.腺泡细胞来源的外泌体miR-130a-3p通过靶向星状细胞PPAR-γ调控胰腺纤维化
J Inflamm Res. 2021 Feb 24;14:461-477. doi: 10.2147/JIR.S299298. eCollection 2021.
7
Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway.缺氧胰腺星状细胞衍生的外泌体 mirnas 通过 PTEN/AKT 通路促进胰腺癌的增殖和侵袭。
Aging (Albany NY). 2021 Feb 26;13(5):7120-7132. doi: 10.18632/aging.202569.
8
The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives.星状细胞在胰腺导管腺癌中的作用：靶向治疗前景
Front Oncol. 2021 Jan 14;10:621937. doi: 10.3389/fonc.2020.621937. eCollection 2020.
9
The effects of nuclear factor-kappa B in pancreatic stellate cells on inflammation and fibrosis of chronic pancreatitis.核因子-κB 在胰腺星状细胞对慢性胰腺炎炎症和纤维化的影响。
J Cell Mol Med. 2021 Feb;25(4):2213-2227. doi: 10.1111/jcmm.16213. Epub 2020 Dec 30.
10
Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma.缺氧基质释放的可溶性化合物赋予胰腺导管腺癌侵袭性。
Biomedicines. 2020 Oct 22;8(11):444. doi: 10.3390/biomedicines8110444.
Zotero 插件