铬催化未活化的碳（芳基）-磷键的裂解
Catalytic Cleavage of Unactivated C(aryl)-P Bonds by Chromium.
作者信息
Tang Jinghua, Ling Liang, Yuan Shuqing, Luo Meiming, Zeng Xiaoming
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
出版信息
Org Lett. 2022 Mar 4;24(8):1581-1586. doi: 10.1021/acs.orglett.1c04325. Epub 2022 Feb 24.
We describe here the coupling to transform aryl phosphine derivatives by the cleavage of unactivated C(aryl)-P bonds with chromium catalysis, allowing us to achieve the reaction with alkyl bromides and arylmagnesium reagents under mild conditions. Mechanistic studies indicate that catalytic cleavage of unactivated C(aryl)-P bonds is due to the in situ formed reactive Cr, followed by transmetalation and coupling with alkyl bromides.
我们在此描述了通过铬催化裂解未活化的C(芳基)-P键来实现芳基膦衍生物转化的偶联反应，这使我们能够在温和条件下实现与烷基溴和芳基镁试剂的反应。机理研究表明，未活化的C(芳基)-P键的催化裂解是由于原位形成的活性铬，随后发生金属转移并与烷基溴偶联。
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