Eğilmez Oğuz Kadir, Tunç Abdülkadir, Yılmaz Mahmut Sinan, Şahiner Büşra Gebeş, Koçoğlu Mehmet, Eryılmaz Halil Alper, Güven Mehmet
Department of Otorhinolaryngology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
Department of Neurology, Sakarya University Training and Research Hospital, Sakarya, Turkey.
Acta Otolaryngol. 2022 Feb;142(2):168-174. doi: 10.1080/00016489.2022.2039759. Epub 2022 Feb 24.
Brainstem involvement (BSI) has been reported as a major predictive factor for future disability in Multiple Sclerosis (MS).
AIMS/OBJECTIVES: To evaluate whether Cervical Vestibular Evoked Myogenic Potentials (cVEMPs) and Video Head Impulse Test (vHIT) can be used to detect demyelinating lesions in vestibular pathways in MS.
Fifty three people with MS and 40 controls were evaluated with Dizziness Handicap Inventory (DHI), vHIT and cVEMP.
The median value of DHI in MS group was significantly higher than controls (<.001). According to vHIT results, while the results of horizontal canal vestibulo-ocular reflex gain in group with brain stem involvement (gBSI (+)) were significantly different from both controls and group without brain stem involvement (gBSI (-)) (= .036 and .024, respectively), results of gBSI (-) were similar with controls (= .858). When cVEMP results were examined, mean P1 wave latency in gBSI (+) was significantly longer than controls (= .002), but difference between gBSI (-) and controls and gBSI (+) was not statistically significant (= .104 and .279, respectively).
vHIT and cVEMP can be used in diagnosis and follow-up of people with MS without demyelinating brainstem lesions on MRI.
脑干受累（BSI）已被报道为多发性硬化症（MS）未来残疾的主要预测因素。
评估颈前庭诱发肌源性电位（cVEMP）和视频头脉冲试验（vHIT）是否可用于检测MS患者前庭通路中的脱髓鞘病变。
对53例MS患者和40例对照者进行头晕残障量表（DHI）、vHIT和cVEMP评估。
MS组DHI的中位数显著高于对照组（<.001）。根据vHIT结果，脑干受累组（gBSI（+））水平半规管前庭眼反射增益结果与对照组和无脑干受累组（gBSI（-））均有显著差异（分别为.036和.024），而gBSI（-）组结果与对照组相似（=.858）。检查cVEMP结果时，gBSI（+）组的平均P1波潜伏期显著长于对照组（=.002），但gBSI（-）组与对照组以及gBSI（+）组之间的差异无统计学意义（分别为.104和.279）。
vHIT和cVEMP可用于MRI上无脱髓鞘脑干病变的MS患者的诊断和随访。
