内镜活检对黏液性结直肠癌的诊断效率不足。
Endoscopy biopsy is not efficiency enough for diagnosis of mucinous colorectal adenocarcinoma.
作者信息
Xiao Shuai, Huang Jia, Zhang Yiwei, Tang Rong, Xu Yunhua, He Rongfang, Huang Qiulin, Ouyang Jun, Zu Xuyu, Peng Xiuda, Fu Kai
机构信息
The First Affiliated Hospital, Institute of Oncology, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
The First Affiliated Hospital, Department of Gastrointestinal Surgery, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
出版信息
Discov Oncol. 2021 Oct 25;12(1):44. doi: 10.1007/s12672-021-00443-4.
BACKGROUND
Endoscopy biopsy (EB) is the standard diagnostic method for colorectal cancer (CRC), whereas its accuracy and efficiency in mucinous adenocarcinoma (MAC) initial diagnosis is unclear.
METHODS
The initial EB and postoperative specimen (PS) pathological diagnosis of MAC from two centers were retrospectively collected and analyzed. The accuracy and efficiency of initial EB compared with PS pathological diagnosis were analyzed. The potential factors which would affect the initial EB diagnosis of MAC were analyzed.
RESULTS
280 and 78 eligible cases were enrolled in this study from two centers respectively. The initial EB diagnosis accuracy for MAC were 84.62% and 83.33%. However, among the cases of PS diagnosis with MAC, the diagnostic efficiency of initial EB was only 36.49% and 32.50% respectively. Lower tumor differentiation and more EB number were associated with an increased probability for the EB diagnosis of MAC, but only tumor differentiation was an independent diagnositic factor for EB in the two cohorts.
CONCLUSIONS
The accuracy of initial EB with MAC is high, but the diagnostic efficiency was extremely low. Tumor differentiation and EB number were associated with the diagnosis efficiency of MAC before surgery.
背景
内镜活检（EB）是结直肠癌（CRC）的标准诊断方法，但其在黏液腺癌（MAC）初始诊断中的准确性和效率尚不清楚。
方法
回顾性收集并分析两个中心MAC的初始EB及术后标本（PS）病理诊断结果。分析初始EB与PS病理诊断相比的准确性和效率。分析影响MAC初始EB诊断的潜在因素。
结果
本研究分别从两个中心纳入280例和78例符合条件的病例。MAC的初始EB诊断准确率分别为84.62%和83.33%。然而，在PS诊断为MAC的病例中，初始EB的诊断效率分别仅为36.49%和32.50%。肿瘤分化程度较低和EB次数较多与EB诊断MAC的概率增加相关，但在两个队列中只有肿瘤分化程度是EB的独立诊断因素。
结论
MAC初始EB的准确性较高，但诊断效率极低。肿瘤分化程度和EB次数与术前MAC的诊断效率相关。
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