Dermatologie, Clínica, Cirurgia e Laser, São Paulo-SP, Brazil.
Departamento de Dermatologia da FMB-Unesp, Botucatu-SP, Brazil.
J Cosmet Dermatol. 2022 May;21(5):1940-1947. doi: 10.1111/jocd.14879. Epub 2022 Mar 14.
Facial aging is a complex process, which, beyond a genetic predisposition, involves both physical and environmental factors. Even identical twins with the same genetic load may differ substantially in facial wrinkles and aging, demanding a personalized treatment approach.
To demonstrate the ONE21 technique as an excellent tool to a customized assessment and IncobotulinuntoxinA treatment to address phenotype discordances and epigenetic drifts in identical twins, expressed by different patterns of upper face muscle contractions and wrinkles intensity.
PATIENTS/METHODS: Five pairs of identical Caucasian twin sisters, from 30 to 45 years of age, were evaluated for hyperfunctional upper facial wrinkles (forehead, glabella, and periorbital), assessing the individual anatomy, muscle function and habitual facial movements of each patient. All the subjects were treated with the ONE21 technique using IncobotulinumtoxinA and reevaluated 30 days after the procedure.
Though the clinical-anatomical pattern of the forehead contraction was similar between the pairs, the strength of the muscles, the number and depth of wrinkles differed. This varied presentation demanded distinct points of distribution and dosages of incobotulinumtoxinA for all the twins, according to the ONE21 approach. The results 30 days after treatment were satisfactory in all the subjects.
The ONE21 technique allows an objective and careful evaluation of the wrinkles of the upper face, based on an individualized assessment, which may vary even in identical twins.
面部衰老过程复杂，除遗传易感性外，还涉及多种物理和环境因素。即使遗传负荷相同的同卵双胞胎，其面部皱纹和衰老也可能存在显著差异，这就需要采用个性化的治疗方法。
展示 ONE21 技术作为一种出色的工具，可对同卵双胞胎进行定制评估和注射 IncobotulinumtoxinA 治疗，以解决表型差异和表观遗传漂变，这些差异表现为上脸肌肉收缩和皱纹强度的不同模式。
患者/方法：评估了 5 对 30 至 45 岁的白种人同卵双胞胎的上脸过度活跃性皱纹（额部、眉间和眶周），评估了每位患者的个体解剖结构、肌肉功能和习惯性面部运动。所有受试者均采用 ONE21 技术使用 IncobotulinumtoxinA 治疗，并在治疗后 30 天进行重新评估。
尽管双胞胎之间额部收缩的临床解剖模式相似，但肌肉强度、皱纹的数量和深度存在差异。这种不同的表现需要根据 ONE21 方法为所有双胞胎确定不同的注射点和剂量。治疗 30 天后，所有受试者的结果均令人满意。
ONE21 技术允许根据个体评估对面部上区皱纹进行客观、细致的评估，即使是同卵双胞胎也可能存在差异。
