Promises of Functionally Graded Material in Bone Regeneration: Current Trends, Properties, and Challenges.

Functionally graded materials (FGMs) are emerging materials systems, with structures and compositions gradually changing in a particular direction. Consequently, the properties of the materials gradually change in the desired direction to achieve particular nonhomogeneous service demands without abrupting the compositional and behavioral interface at the macroscale. FGMs have been found to have high potential as orthopedic implants; because the functional gradient can be adapted in such a manner that the core of FGM should be compatible with the density and strength of bone, interlayers can maintain the structural integrity and outermost layers would provide bioactivity and corrosion resistance, thus overall tailoring the stress shielding effect. This review article discusses the typical FGM systems existing in nature and the human body, focusing on bone tissue. Further, the reason behind the application of these FGMs systems in orthopedic implants is explored in detail, considering the physical and biological necessities. The substantial focus of the present critical review is devoted to two primary topics related to the usage of FGMs for orthopedic implants: (1) the synthesizing techniques currently available to produce FGMs for load-bearing orthopedic applications and (2) the properties, such as mechanical, structural, and biological behavior of the FGMs. This review article gives an insight into the potential of FGMs for orthopedic applications.