Veterinary Teaching Hospital, Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
Blue Pearl Veterinary Partners, New York, NY.
J Am Vet Med Assoc. 2022 Feb 24;260(7):735-740. doi: 10.2460/javma.20.12.0683.
To evaluate the effect on seizure frequency of add-on telmisartan treatment in dogs with refractory idiopathic epilepsy.
11 client-owned dogs with idiopathic epilepsy and ≥ 2 generalized seizures/mon that were currently being treated with ≥ 2 antiepileptic drugs.
Telmisartan was administered at a dosage of 0.25 to 1 mg/kg, PO, every 12 hours for 4 to 16 months. Seizure frequencies before and during telmisartan treatment were recorded.
10 dogs completed the 4-month treatment protocol. One dog was excluded owing to a transient increase in serum creatinine concentration; no adverse effects of telmisartan were observed in the remaining 10 dogs. A reduction in seizure frequency greater than an estimated expected placebo effect of 30% was evident in 7 of the 10 dogs. Long-term (12 to 16 months) follow-up information was available for 6 dogs, of which 4 had a further reduction in seizure frequency. Differences in seizure frequency were not statistically significant. No significant difference was found in serum phenobarbital concentration throughout the treatment period in the 7 dogs that were tested.
Telmisartan has the potential to reduce seizure frequency when administered as an add-on antiepileptic drug in dogs with refractory idiopathic epilepsy. A randomized, double-blind, placebo-controlled trial is needed to determine the true efficacy of telmisartan. On the basis of our results, a sample size of 54 dogs with refractory idiopathic epilepsy would be needed.
评估添加替米沙坦治疗对难治性特发性癫痫犬癫痫发作频率的影响。
11 只特发性癫痫伴≥2 次全身性发作/月的患犬，目前正在用≥2 种抗癫痫药物治疗。
替米沙坦按 0.25 至 1 mg/kg、PO、每 12 小时 1 次的剂量给药，连续 4 至 16 个月。记录替米沙坦治疗前后的癫痫发作频率。
10 只犬完成了 4 个月的治疗方案。1 只犬因血清肌酐浓度短暂升高而被排除；其余 10 只犬未观察到替米沙坦的不良反应。10 只犬中有 7 只癫痫发作频率降低大于预计的安慰剂效应 30%。6 只犬可获得 12 至 16 个月的长期随访信息，其中 4 只犬癫痫发作频率进一步降低。差异无统计学意义。在接受检测的 7 只犬中，整个治疗期间血清苯巴比妥浓度无显著差异。
替米沙坦作为添加型抗癫痫药物用于治疗难治性特发性癫痫犬，具有降低癫痫发作频率的潜力。需要进行随机、双盲、安慰剂对照试验来确定替米沙坦的真实疗效。根据我们的结果，需要 54 只难治性特发性癫痫犬的样本量。
