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综述:厚壳贻贝:一种必不可少的、低成本的模式生物,用于研究外源性化学物质对氧化应激和公共健康的影响。

Review: Mytilus galloprovincialis: An essential, low-cost model organism for the impact of xenobiotics on oxidative stress and public health.

机构信息

Department of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, Carol I Avenue, 20A, Iasi, Romania.

Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale, Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.

出版信息

Comp Biochem Physiol C Toxicol Pharmacol. 2022 Jun;256:109302. doi: 10.1016/j.cbpc.2022.109302. Epub 2022 Feb 22.

Abstract

The level of pollution becomes more and more of a pressuring matter for humankind at a worldwide level. Often the focus is on the effects that we can directly and see such as decreased air quality and higher than normal temperatures and weather, but the effects we cannot see are frequently overlooked. For at least the past decade increasing importance has been given towards the effects of pollution of living animals or non-target organisms and plants. For this purpose, one model animal that surfaced is the purpose, one model animal surfaced is Mytilus galloprovincialis. As all mussels, this species is capable of bio-accumulating important quantities of different xenobiotics such as pesticides, paints, medicines, heavy metals, industrial compounds, and even compounds marketed as antioxidants and antivirals. Their toxic effects can be assessed through their impact on oxidative stress, lysosomal membrane stability, and cell viability through trypan blue exclusion test and neutral red retention assay techniques. The purpose of this paper is to highlight the benefits of using M. galloprovincialis as an animal model for toxicological assays of various classes of xenobiotics by bringing to light the studies that have approached the matter.

摘要

在全球范围内,污染程度越来越成为人类面临的一个紧迫问题。人们通常关注的是那些我们能够直接感受到的影响,如空气质量下降、气温高于正常水平和极端天气等,但那些我们无法看到的影响往往被忽视了。至少在过去十年中,人们越来越重视污染对活体动物或非目标生物和植物的影响。为此,一种浮出水面的模式动物是贻贝。作为所有贻贝,这个物种能够生物积累大量不同的外源性物质,如农药、油漆、药品、重金属、工业化合物,甚至被宣传为抗氧化剂和抗病毒剂的化合物。可以通过使用台盼蓝排斥试验和中性红保留试验技术来评估它们对氧化应激、溶酶体膜稳定性和细胞活力的影响来评估它们的毒性作用。本文的目的是通过阐明已经研究过这个问题的研究,强调使用贻贝作为各种外源性物质毒理学检测的动物模型的好处。

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