Tintner R, Brown P, Hedley-Whyte E T, Rappaport E B, Piccardo C P, Gajdusek D C
Neurology. 1986 Jul;36(7):932-6. doi: 10.1212/wnl.36.7.932.
Beginning at age 12, a boy with idiopathic hypopituitarism was treated with cadaver pituitary-derived human growth hormone during the period from 1963 to 1969. Fifteen years after the last treatment, the then 32-year-old man developed Creutzfeldt-Jakob disease (CJD). The illness was atypical in showing predominantly cerebellar signs, little mental deterioration, and no abnormal movements or periodic EEG activity. Examination of the embalmed brain, 7 months after interment, revealed the characteristic changes of CJD mainly in the cerebellum and basal ganglia. This case establishes the contamination of at least two American lots of human growth hormone and, together with other cases of iatrogenic disease, suggests that virus enters the brain from the blood, rather than along neural pathways.
一名患有特发性垂体功能减退症的男孩从12岁开始，在1963年至1969年期间接受了尸体垂体来源的人生长激素治疗。在最后一次治疗15年后，当时32岁的男子患上了克雅氏病（CJD）。该病例表现不典型，主要表现为小脑体征，精神衰退轻微，无异常运动或周期性脑电图活动。在埋葬7个月后对防腐处理的大脑进行检查，发现克雅氏病的特征性变化主要位于小脑和基底神经节。该病例证实至少有两批美国生产的人生长激素受到污染，并且与其他医源性疾病病例一起表明，病毒是从血液进入大脑，而非沿神经通路进入。
