Raskin N H
Neurology. 1986 Jul;36(7):995-7. doi: 10.1212/wnl.36.7.995.
For patients with chronic intractable headache, we compared a new treatment and a traditional one. Fifty-five patients (36 dependent on ergotamine, analgesics, diazepam, or corticosteroids) were given IV dihydroergotamine (DHE) and metoclopramide every 8 hours. Fifty-four age- and sex-matched patients (38 drug-dependent) were given diazepam intravenously every 8 hours. Forty-nine of the 55 DHE-treated patients became headache-free within 48 hours, and 39 of them sustained benefits in a mean follow-up of 16 months. In contrast, 7 diazepam-treated patients became free of headache within 3 to 6 days, and 31 had improved somewhat in 10 days. Repetitive IV DHE helps to terminate cycles of intractable migraine.
对于慢性顽固性头痛患者，我们比较了一种新疗法和一种传统疗法。55名患者（36名对麦角胺、镇痛药、地西泮或皮质类固醇有依赖）每8小时静脉注射二氢麦角胺（DHE）和甲氧氯普胺。54名年龄和性别匹配的患者（38名药物依赖者）每8小时静脉注射地西泮。55名接受DHE治疗的患者中有49名在48小时内头痛消失，其中39名在平均16个月的随访中持续受益。相比之下，7名接受地西泮治疗的患者在3至6天内头痛消失，31名在10天内有所改善。重复静脉注射DHE有助于终止顽固性偏头痛的发作周期。
