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急性大脑中动脉远段闭塞静脉注射组织型纤溶酶原激活剂后的出血性转化

Hemorrhagic Transformation after Intravenous Tissue Plasminogen Activator Administration in Acute Distal Middle Cerebral Artery Occlusion.

作者信息

Lee Chan-Hyuk, Yi Sang Hak, Shin Byoung-Soo, Kang Hyun Goo

机构信息

Department of Neurology, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Korea.

Department of Neurology, Wonkwang University School of Medicine, Iksan 54538, Korea.

出版信息

Diagnostics (Basel). 2022 Feb 3;12(2):398. doi: 10.3390/diagnostics12020398.

DOI:10.3390/diagnostics12020398
PMID:35204489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8871517/
Abstract

Atrial fibrillation and cerebral embolism are known to increase the risk of hemorrhagic transformation (HT). In addition, a sufficient number of collateral vessels in acute ischemic stroke can maintain the ischemic penumbra and prevent progression to the ischemic core, while an insufficient number of collateral vessels increase the HT risk after therapeutic recanalization. In this case, when the middle cerebral artery is recanalized, reperfusion injury may occur in the basal ganglia due to insufficient collateral vessels.

摘要

已知心房颤动和脑栓塞会增加出血性转化(HT)的风险。此外,急性缺血性卒中时足够数量的侧支血管可维持缺血半暗带并防止进展为缺血核心,而侧支血管数量不足会增加治疗性再通后发生HT的风险。在这种情况下,当中脑动脉再通时,由于侧支血管不足,基底节可能会发生再灌注损伤。

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Hemorrhagic Transformation after Intravenous Tissue Plasminogen Activator Administration in Acute Distal Middle Cerebral Artery Occlusion.急性大脑中动脉远段闭塞静脉注射组织型纤溶酶原激活剂后的出血性转化
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本文引用的文献

1
Predictors and clinical relevance of hemorrhagic transformation after endovascular therapy for anterior circulation large vessel occlusion strokes: a multicenter retrospective analysis of 1122 patients.前循环大血管闭塞性卒中血管内治疗后出血转化的预测因素及临床相关性:1122例患者的多中心回顾性分析
J Neurointerv Surg. 2015 Jan;7(1):16-21. doi: 10.1136/neurintsurg-2013-010743. Epub 2014 Jan 8.
2
Collateral flow averts hemorrhagic transformation after endovascular therapy for acute ischemic stroke.侧支血流可预防急性缺血性脑卒中血管内治疗后的出血性转化。
Stroke. 2011 Aug;42(8):2235-9. doi: 10.1161/STROKEAHA.110.604603. Epub 2011 Jul 7.
3
Observations on brain embolism with special reference to the mechanism of hemorrhagic infarction.
关于脑栓塞的观察,特别提及出血性梗死的机制。
J Neuropathol Exp Neurol. 1951 Jan;10(1):92-4.