Schwartz J, Ott C, Morales O, Reid I A
Peptides. 1986 Jan-Feb;7(1):91-6. doi: 10.1016/0196-9781(86)90067-7.
The nature of the activity of vasopressin which is responsible for the inhibition of renin secretion was studied by comparing the effects of vasopressin (AVP) and analogs of AVP in anesthetized water-loaded dogs. Infusion of AVP (1.0 ng/kg/min) increased mean arterial pressure (MAP) and decreased heart rate (HR) and free water clearance (CH2O). Plasma renin activity (PRA) decreased from 11.9 +/- 4.7 to 3.8 +/- 1.7 ng/ml/3 hr (p less than 0.05). A selective antidiuretic agonist, 1-deamino-8-D-arginine vasopressin (1.0 ng/kg/min), which had no effect on MAP or HR but was effective as AVP in decreasing CH2O, decreased PRA from 13.5 +/- 4.6 to 7.0 +/- 2.9 ng/ml/3 hr (p less than 0.05). Infusion of a selective vasoconstrictor agonist, 2-phenylalanine-8-ornithine oxytocin (1.0 ng/kg/min), increased MAP and decreased HR but did not decrease CH2O or PRA. A vasoconstrictor antagonist, d(CH2)5Tyr(Me)AVP (10 micrograms/kg), completely blocked the MAP and HR responses to AVP but did not block the decrease in CH2O or PRA (5.9 +/- 1.8 to 2.9 +/- 1.6 ng/ml/3 hr) (p less than 0.001). Infusion of the 0.45% saline vehicle had no significant effect on MAP, HR, CH2O or PRA. These results indicate that the inhibition of renin secretion by vasopressin in anesthetized water-loaded dogs is due to its antidiuretic activity.
通过比较血管加压素（AVP）及其类似物对麻醉状态下饮水负荷犬的影响，研究了负责抑制肾素分泌的血管加压素活性的本质。输注AVP（1.0 ng/kg/分钟）可提高平均动脉压（MAP），降低心率（HR）和自由水清除率（CH2O）。血浆肾素活性（PRA）从11.9±4.7降至3.8±1.7 ng/ml/3小时（p<0.05）。一种选择性抗利尿激动剂，1-去氨基-8-D-精氨酸血管加压素（1.0 ng/kg/分钟），对MAP或HR无影响，但在降低CH2O方面与AVP一样有效，可使PRA从13.5±4.6降至7.0±2.9 ng/ml/3小时（p<0.05）。输注一种选择性血管收缩激动剂，2-苯丙氨酸-8-鸟氨酸催产素（1.0 ng/kg/分钟），可提高MAP并降低HR，但不降低CH2O或PRA。一种血管收缩拮抗剂，d(CH2)5Tyr(Me)AVP（10微克/千克），完全阻断了对AVP的MAP和HR反应，但未阻断CH2O或PRA的降低（从5.9±1.8降至2.9±1.6 ng/ml/3小时）（p<0.001）。输注0.45%盐水载体对MAP、HR、CH2O或PRA无显著影响。这些结果表明，在麻醉状态下饮水负荷犬中，血管加压素对肾素分泌的抑制作用是由于其抗利尿活性。
