SOX10 上游缺失导致鸡出现浅黄色羽毛颜色。
A Deletion Upstream of SOX10 Causes Light Yellow Plumage Colour in Chicken.
机构信息
National Engineering Laboratory for Animal Breeding, Department of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Beijing Municipal Bureau of Agriculture and Rural Affairs, Beijing 100005, China.
出版信息
Genes (Basel). 2022 Feb 10;13(2):327. doi: 10.3390/genes13020327.
Chicken plumage colour is a complex trait controlled by many genes. Herein, through Rhode Island Red (RIR) and White Leghorn (WL) F1 cross populations, the segregation of plumage color was observed in females, showing white in males, and dark red (DR) and light yellow (LY) in females. The white has been found to be caused by dominant white alleles () and the DR phenotype is attributed to a sex-linked recessive silver allele (S∗S). LY is a derived feather colour phenotype and the genetic mechanism of this is unclear. In order to explore the genetic basis for LY, we randomly selected 40 DR and 39 LY chickens for paired-end sequencing. Through the use of association analysis, we found the LY phenotype is caused by a 7.6 kb non-coding deletion near the SOX10 gene. This mutation has been reported to be responsible for dark brown plumage in chicken, and subsequent diagnostic PCR tests showed that the length of the long-range non-coding deletion is 7.6 kb instead of 8.3 kb as previously reported.
鸡的羽毛颜色是由许多基因控制的复杂特征。在此，通过 Rhode Island Red（RIR）和 White Leghorn（WL）F1 杂交群体，观察到雌性的羽毛颜色分离，雄性为白色，雌性为深红色（DR）和浅黄色（LY）。已经发现白色是由显性白色等位基因（）引起的，DR 表型归因于性连锁隐性银色等位基因（S∗S）。LY 是一种衍生的羽毛颜色表型，其遗传机制尚不清楚。为了探索 LY 的遗传基础，我们随机选择了 40 只 DR 和 39 只 LY 鸡进行配对末端测序。通过关联分析，我们发现 LY 表型是由 SOX10 基因附近的 7.6kb 非编码缺失引起的。该突变已被报道负责鸡的深棕色羽毛，随后的诊断 PCR 测试表明，长距离非编码缺失的长度为 7.6kb，而不是之前报道的 8.3kb。
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