Su Gao-Jian, Gao Jie, Wu Chu-Wei, Zou Jun-Feng, Zhang Di, Zhu Dong-Liang, Liu Jun, Zhang Jie-Hua, Huang Xian-Jian
Shenzhen Key Laboratory of Neurosurgery, Department of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518000, China.
J Clin Med. 2022 Feb 9;11(4):902. doi: 10.3390/jcm11040902.
Chronic subdural hematoma (CSDH) is a common neurological disease that involves the collection of blood products in the subdural space. The progression of CSDH is an angiogenic and inflammatory process, but the multifactorial mechanisms underlying CSDH are still not fully understood. We aimed to identify one or more factors that may play an important role in the development of CSDH. We enrolled 83 patients with CSDH, including 17 postoperative patients, and analyzed 20 markers in the hematoma fluid and peripheral blood of each patient. Overall differential gene expression was examined to identify the representative markers. The concentration of MMP-8 was significantly lower in the postoperative group than in the preoperative group. The concentration of MMP-9 was significantly higher in the postoperative group than in the preoperative group. These findings indicate that MMP-8 and MMP-9 may play important roles in the pathophysiology of CSDH. Understanding the pathways associated with CSDH may provide insights for improving disease outcomes.
慢性硬膜下血肿（CSDH）是一种常见的神经系统疾病，涉及硬膜下间隙血液产物的积聚。CSDH的进展是一个血管生成和炎症过程，但CSDH潜在的多因素机制仍未完全了解。我们旨在确定一个或多个可能在CSDH发展中起重要作用的因素。我们纳入了83例CSDH患者，包括17例术后患者，并分析了每位患者血肿液和外周血中的20种标志物。通过检查总体差异基因表达来确定代表性标志物。术后组MMP-8浓度显著低于术前组。术后组MMP-9浓度显著高于术前组。这些发现表明MMP-8和MMP-9可能在CSDH的病理生理学中起重要作用。了解与CSDH相关的途径可能为改善疾病预后提供思路。
