评估慢性硬脑膜下血肿患者外周血炎性标志物。
Assessment of peripheral blood cell inflammatory markers in patients with chronic subdural hematoma.
机构信息
Department of Neurosurgery, First Affiliated Hospital of China Medical, University, Shenyang, China.
Department of Neurosurgery, First Affiliated Hospital of China Medical, University, Shenyang, China.
出版信息
Clin Neurol Neurosurg. 2020 Apr;191:105738. doi: 10.1016/j.clineuro.2020.105738. Epub 2020 Feb 17.
OBJECTIVES
We aimed to study the role of peripheral blood cell inflammatory markers in patients with chronic subdural hematoma (CSDH).
PATIENTS AND METHODS
We enrolled 466 patients with CSDH and 150 healthy controls and retrospectively analyzed peripheral blood cell inflammatory markers, including neutrophils, platelets, lymphocytes, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). Subsequently, we performed a subgroup analysis of the patients with CSDH based on gender, age, trauma history, and unilateral or bilateral hematoma.
RESULTS
The CSDH group had higher numbers of neutrophils and platelets, as well as a higher NLR and PLR, than those in the healthy control group. Further, compared with the healthy control group, the CSDH group had lower lymphocyte counts. Subgroup analysis indicated trauma history as the only significant factor.
CONCLUSION
Peripheral blood cell inflammatory markers could serve as indexes for evaluating the inflammatory state in patients with CSDH. There is a need for further studies on the prognostic role of this index in patients with CSDH.
目的
研究慢性硬脑膜下血肿（CSDH）患者外周血细胞炎性标志物的作用。
患者与方法
我们纳入了 466 例 CSDH 患者和 150 例健康对照者，并回顾性分析了外周血细胞炎性标志物，包括中性粒细胞、血小板、淋巴细胞、中性粒细胞/淋巴细胞比值（NLR）和血小板/淋巴细胞比值（PLR）。随后，我们根据患者的性别、年龄、创伤史以及血肿的单侧或双侧进行了 CSDH 患者的亚组分析。
结果
CSDH 组的中性粒细胞和血小板数量以及 NLR 和 PLR 均高于健康对照组。此外，与健康对照组相比，CSDH 组的淋巴细胞计数较低。亚组分析表明，创伤史是唯一显著的因素。
结论
外周血细胞炎性标志物可作为评估 CSDH 患者炎症状态的指标。需要进一步研究该指标在 CSDH 患者中的预后作用。
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