Hannappe Marc-Antoine, Baudin Florian, Mariet Anne-Sophie, Gabrielle Pierre-Henri, Arnould Louis, Bron Alain M, Creuzot-Garcher Catherine
Ophthalmology Department, University Hospital of Dijon, 21000 Dijon, France.
Physiopathologie et Epidémiologie Cérébro-Cardiovasculaires (PEC2, EA 7460), Burgundy University, 21000 Dijon, France.
J Clin Med. 2022 Feb 11;11(4):946. doi: 10.3390/jcm11040946.
The effect of intraocular injections of anti-vascular endothelial growth factor (VEGF) on intraocular pressure (IOP) has not been clearly stated. We extracted data from the electronic health records at Dijon University Hospital of 750 patients who were unilaterally injected with anti-VEGF agents between March 2012 and March 2020. These were treatment-naïve patients who had received at least three injections of the same treatment (aflibercept, bevacizumab, or ranibizumab) in one eye only, and had IOP measurements before and after the injections. Fellow untreated eyes were used as comparators. A clinically significant IOP rise was determined as an IOP above 21 mmHg and an increase of at least 6 mmHg compared to baseline, or the need for IOP-lowering agents. We found an overall slight increase in IOP between treated and untreated eyes at 6 months (+0.67 ± 3.33 mmHg, 95% confidence interval 0.33-1.02, < 0.001). Ranibizumab had a higher final IOP at 1 and 3 months. Age, sex, and the number of injections were not associated with IOP variation. Ranibizumab was associated with a higher rate of increase in clinically significant IOP at 6 months ( = 0.03). Our study confirms that anti-VEGF injections constitute a relatively safe treatment regarding their impact on IOP.
玻璃体内注射抗血管内皮生长因子（VEGF）对眼压（IOP）的影响尚未明确阐述。我们从第戎大学医院的电子健康记录中提取了2012年3月至2020年3月期间750名单侧注射抗VEGF药物患者的数据。这些患者之前未接受过治疗，仅单眼接受了至少三次相同治疗（阿柏西普、贝伐单抗或雷珠单抗）注射，且在注射前后均测量了眼压。未治疗的对侧眼用作对照。临床上显著的眼压升高定义为眼压高于21 mmHg且较基线升高至少6 mmHg，或需要使用降眼压药物。我们发现，治疗眼和未治疗眼在6个月时眼压总体略有升高（+0.67±3.33 mmHg，95%置信区间0.33 - 1.02，<0.001）。雷珠单抗在1个月和3个月时的最终眼压较高。年龄、性别和注射次数与眼压变化无关。雷珠单抗在6个月时临床上显著眼压升高的发生率较高（ = 0.03）。我们的研究证实，抗VEGF注射对眼压的影响相对安全。
