Garrido Castillo Laura Nalleli, Mejean Arnaud, Vielh Philippe, Anract Julien, Decina Alessandra, Nalpas Bertrand, Benali-Furet Naoual, Desitter Isabelle, Paterlini-Bréchot Patrizia
Institut Necker Enfants Malades (INEM), INSERM U1151, Faculté de Médecine, Université de Paris, 75015 Paris, France.
INSERM U807, Faculté de Médecine, Université de Paris, 75015 Paris, France.
Life (Basel). 2022 Jan 22;12(2):165. doi: 10.3390/life12020165.
There is an unmet need for reliable biomarkers to predict prostate cancer recurrence after prostatectomy in order to better guide the choice of surgical treatment. We have evaluated the predictive value of the preoperative detection of Circulating Tumor Cells (CTC) for prostate cancer recurrence after surgery. A cohort of 108 patients with non-metastatic prostate adenocarcinoma undergoing radical prostatectomy was tested for the presence of CTC before prostatectomy using ISET. Disease recurrence was assessed by the increase in serum PSA level after prostatectomy. The following factors were assessed for statistical association with prostate cancer recurrence: the presence of CTC, serum PSA, Gleason score, and pT stage using univariate and multivariate analyses, with a mean follow-up of 34.9 months. Prostate cancer recurrence was significantly associated with the presence of at least 1 CTC at the preoperative time point ( < 0.001; Predictive value = 0.83). Conversely, the absence of prostate cancer recurrence was significantly associated with the lack of CTC detection at diagnosis (Predictive value = 1). Our multivariate analysis shows that only CTC presence is an independent risk factor associated with prostate cancer recurrence after prostatectomy ( < 0.001). Our results suggest that CTC detection by ISET before surgery is an interesting candidate predictive marker for cancer recurrence in patients with non-metastatic PCa.
为了更好地指导手术治疗的选择，对于预测前列腺切除术后前列腺癌复发的可靠生物标志物存在未满足的需求。我们评估了术前检测循环肿瘤细胞（CTC）对前列腺癌术后复发的预测价值。使用ISET对108例接受根治性前列腺切除术的非转移性前列腺腺癌患者队列在前列腺切除术前检测CTC的存在情况。通过前列腺切除术后血清PSA水平的升高来评估疾病复发情况。使用单因素和多因素分析评估以下因素与前列腺癌复发的统计学关联：CTC的存在、血清PSA、Gleason评分和pT分期，平均随访34.9个月。前列腺癌复发与术前时间点至少存在1个CTC显著相关（<0.001；预测值=0.83）。相反，前列腺癌未复发与诊断时未检测到CTC显著相关（预测值=1）。我们的多因素分析表明，只有CTC的存在是与前列腺切除术后前列腺癌复发相关的独立危险因素（<0.001）。我们的结果表明，术前通过ISET检测CTC是未转移性前列腺癌患者癌症复发的一个有意义的候选预测标志物。
