Nguweneza Arthemon, Oosterwyk Chandré, Banda Kambe, Nembaware Victoria, Mazandu Gaston, Kengne Andre P, Wonkam Ambroise
Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa.
Expert Rev Hematol. 2022 Apr;15(4):359-368. doi: 10.1080/17474086.2022.2043743. Epub 2022 Feb 28.
Blood pressure (BP) values ≥120/70 mmHg considerably increase the risk of pulmonary hypertension and renal dysfunction in Sickle Cell Disease (CSD) patients and ultimately increased morbidity and mortality. This has led to the development of the term relative systemic hypertension (RSH). RSH was defined as Systolic BP 120-139 mm Hg or diastolic BP 70-89 mm Hg, whereas systemic hypertension is defined as Systolic BP ≥ 140 mm Hg or diastolic BP ≥ 90 mm Hg. Systematic identification of BP variations and risk factors in SCD patients could promote effective management. This review aimed to identify factors associated with BP variation among SCD patients.
We searched PubMed, Scopus, Web of Science, and Google Scholar up to December 2020 with no geographical or language restrictions. Two reviewers independently screened and summarized data from eligible studies.
Advancing age, gender, higher body weight, hemoglobin, eGFR, triglycerides, greater hematocrit, higher blood viscosity, history of blood transfusion, and targeted variants in and genes were independently associated with the risk of hypertension in SCD patients.
Interventions that consider these risk factors may potentially contribute to lower BP pressure in SCD patients and prevent the development of severe complications.
血压（BP）值≥120/70 mmHg会显著增加镰状细胞病（SCD）患者患肺动脉高压和肾功能不全的风险，并最终增加发病率和死亡率。这导致了相对系统性高血压（RSH）这一术语的出现。RSH被定义为收缩压120 - 139 mmHg或舒张压70 - 89 mmHg，而系统性高血压被定义为收缩压≥140 mmHg或舒张压≥90 mmHg。系统识别SCD患者的血压变化和危险因素有助于进行有效管理。本综述旨在确定SCD患者中与血压变化相关的因素。
我们检索了截至2020年12月的PubMed、Scopus、科学网和谷歌学术，无地域或语言限制。两名评审员独立筛选并总结符合条件研究的数据。
年龄增长、性别、较高体重、血红蛋白、估算肾小球滤过率（eGFR）、甘油三酯、较高的血细胞比容、较高的血液粘度、输血史以及特定基因的靶向变异与SCD患者的高血压风险独立相关。
考虑这些危险因素的干预措施可能有助于降低SCD患者的血压，并预防严重并发症的发生。
